Wolfram H. Gerlich
University of Göttingen
51 Papers
1.4K Citations
Wolfram H. Gerlich is an academic researcher from University of Göttingen. The author has contributed to research in topics: Hepatitis B virus & Virus. The author has an hindex of 27, co-authored 51 publications. Previous affiliations of Wolfram H. Gerlich include Icahn School of Medicine at Mount Sinai & University of Mainz.
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Papers
Malignant transformation of immortalized transgenic hepatocytes after transfection with hepatitis B virus DNA.
TL;DR: These results provide the first demonstration that HBV displays oncogenic potential in an experimental system, and could be useful to functionally identify HBV genes which convey a tumorigenic phenotype.
244
Structural relationships between minor and major proteins of hepatitis B surface antigen.
Werner Stibbe,Wolfram H. Gerlich +1 more
TL;DR: The minor glycoproteins from hepatitis B surface antigen, GP33 and GP36, contain at their carboxy-terminal part the sequence of the major protein P24 which is coded by the pre-S region of the viral DNA.
218
Formation of transmembraneous hepatitis B e-antigen by cotranslational in vitro processing of the viral precore protein.
Volker Bruss,Wolfram H. Gerlich +1 more
TL;DR: Clusters of positive-charged amino acids seem to act as a novel type of translocation stop signal in the biosynthesis and potential function of HBeAg in hepatitis B virus-infected hepatocytes.
145
Precore sequence of hepatitis B virus inducing e antigen and membrane association of the viral core protein
TL;DR: The data suggest that pre-c functions as a signal peptide for the attachment of core protein P25e to cellular membranes, which can explain the not yet understood relation between viremia and HbeAg and the protective role of anti-HBe antibody.
116
Diagnosis of acute and inapparent hepatitis B virus infections by measurement of IgM antibody to hepatitis B core antigen.
TL;DR: IgM antibody to hepatitis B core antigen (anti-HBc) was determined by a reverse enzyme immunoassay and might be a better indicator of hepatitis B thanHBsAg and help differentiage acute from chronic infection in HBsAg-positive patients.
100