Wolfram Engst
21 Papers
37 Citations
Wolfram Engst is an academic researcher. The author has contributed to research in topics: Methyleugenol & Glucosinolate. The author has an hindex of 14, co-authored 21 publications.
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Papers
Mutagenicity of 5-hydroxymethylfurfural in V79 cells expressing human SULT1A1: identification and mass spectrometric quantification of DNA adducts formed.
TL;DR: It is hypothesized that the hepatocarcinogenic potential of HMF originates from the formation of mutagenic SMF, which is prone to react with DNA via nucleophilic substitution.
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Identification of human and murine sulfotransferases able to activate hydroxylated metabolites of methyleugenol to mutagens in Salmonella typhimurium and detection of associated DNA adducts using UPLC-MS/MS methods
TL;DR: Several methyleugenol metabolites are activated to DNA-reactive mutagens in S. typhimurium upon incorporation of appropriate sulfation capacity and methods were developed that may be utilised to analyse DNA samples from human tissues specifically for the possible presence of methyle Eugenol adducts.
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Abundance of DNA adducts of methyleugenol, a rodent hepatocarcinogen, in human liver samples
Kristin Herrmann,Fabian Schumacher,Wolfram Engst,Klaus E. Appel,Kathrin Klein,Ulrich M. Zanger,Hansruedi Glatt +6 more
TL;DR: It is concluded that the exposure to methyleugenol leads to substantial levels of hepatic DNA adducts and, therefore, may pose a significant carcinogenic risk.
Formation of hepatic DNA adducts by methyleugenol in mouse models: drastic decrease by Sult1a1 knockout and strong increase by transgenic human SULT1A1/2
Kristin Herrmann,Wolfram Engst,Walter Meinl,Simone Florian,Alexander Cartus,Dieter Schrenk,Klaus E. Appel,Tobias Nolden,Heinz Himmelbauer,Hansruedi Glatt +9 more
TL;DR: The role of SULT1A enzymes in the formation of hepatic DNA adducts by methyleugenol in the mouse in vivo was investigated, suggesting an important role of detoxifying pathways for this isomer in vivo.
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1-Methoxy-3-indolylmethyl glucosinolate; a potent genotoxicant in bacterial and mammalian cells: Mechanisms of bioactivation.
Hansruedi Glatt,Chimgee Baasanjav-Gerber,Fabian Schumacher,Bernhard H. Monien,Monika Schreiner,Heinz Frank,Albrecht Seidel,Wolfram Engst +7 more
TL;DR: 1-MIM glucosinolate is mutagenic in bacterial and mammalian cells via at least two different metabolites, including alcohol to a TA100-derived strain expressing human sulphotransferase SULT1A1.
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