N-heterocyclic compounds that block cytokine production via inhibition of p38 kinase are disclosed. In one embodiment, compounds of the present invention are represented by Formula (I). Methods of production, pharmaceutical compositions and methods of treating conditions associated with inappropriate p38 kinase activity or TNF-a expression utilizing compounds of the present invention are also disclosed.

N-heterocyclic inhibitors of tnf-alpha expression

Dye mixtures comprising at least one dye of formula together with at least one dye of formula wherein the radicals indicated in the formulae are defined in accordance with the claims, are suitable for dyeing or printing cellulosic fibre materials with good build-up behaviour and yield dyeings of a deep shade having good fastness properties.

Mixtures of reactive dyes and their use

A system and method for sharing and absorbing energy between body parts. In one aspect, the method involves identifying link pivot locations, fixing base components and minimally invasive insertion techniques. In one particular aspect, the system facilitates absorbing energy between members forming a joint such as between articulating bones.

Extra-articular implantable mechanical energy absorbing systems and implantation method

The personal care compositions of the present invention are in the form of an Article comprising a dissolvable fibrous web structure. The fibers of the dissolvable fibrous web structure comprise a surfactant; a water soluble polymeric structurant; and a plasticizer. Additionally the ratio of the water soluble water soluble polymeric structurant to the active agent in the fiber is 3.5 or less.

Dissolvable Fibrous Web Structure Article Comprising Active Agents

The present invention relates to a dissolvable article in the form of a porous dissolvable solid structure, comprising from about 10% to about 50% water soluble polymer; from about 1% to about 25% plasticizer; from about 23% to about 75% surfactant; wherein said surfactants comprise one or more surfactants from Group I, wherein Group I includes anionic surfactants, and one or more surfactants from Group II, wherein Group II includes a surfactant selected from the group consisting of amphoteric, zwitterionic and combinations thereof; wherein the ratio of Group I to Group II surfactants is from about 5: 95 to about 30:70; and wherein said dissolvable article has a density of from about 0.05 g/cm3 to about 0.40 g/cm3.

Personal care composition in the form of an article having a porous, dissolvable solid structure

Polyfunctional reactive dyes of formula (I), with a bridge containing 2 monohalo- or monocarboxypyridinium-triazine groups, are new; in which D = the residue of a mono-, poly- or metal complex azo, anthraquinone, phthalocyanine, formazan, azomethin, dioxazine, phenazine, stilbene, triphenylmethane, xanthene, thioxanthone, nitroaryl, naphthoquinone, pyrenequinone or perylenetetracarbimide dye; R = hydrogen (H), methyl, ethyl or hydroxyethyl; R , R = H or optionally substituted 1-4C alkyl; X = halogen or carboxypyridinium; B = an aliphatic bridge; at least one of R , R and B contains sulpho, sulphato and/or carboxy substituent(s). The bridged disazo dyes of formulae (II) and (III) are excluded. Also claimed are solid dye formulations, especially powders or granulates, containing 30-95 wt.% dye(s) (I) and 5-15 wt.% buffer(s).

Readily soluble polyfunctional reactive dyes

Improved reactive dyes corresponding to the following formula (I) in which the substituents have the meaning given in the description.

Reactive dyes containing a fluoropyrimidine group

Reactive dyestuffs which, in the form of the free acid, have the following formula ##STR1## in which X denotes fluorine, chlorine or bromine and SO 2 -Z denotes a specific reactive radical, the remaining substituents having the meaning given in the description, and show improved fixation yield in dyeing.

Triazine ring-containing reactive dyestuffs, their preparation and use

A metal-free dyestuff of the formula ##STR1## and metal complex thereof wherein: Fb=the radical of a dyestuff selected from the group consisting of mono- or polyazo, anthraquinone, phthalocyanine, formazan, dioxazine and triphenylmethane radicals, B and B'=a direct bond or an aliphatic or aromatic bridge member to a ring C atom of an aromatic-carbocyclic ring or to a ring C or N atom or an aromatic-heterocyclic ring in Fb, X=CH═CH 2 or CH 2 CH 2 --Y, wherein Y=OSO 3 H, SSO 3 H, OCOCH 3 , OPO 3 H 2 , OSO 2 CH 3 , SCN, NHSO 2 CH 3 --, Cl, Br, F, OCOC 6 H 5 , OSO 2 --C 6 H 4 CH 3 , ##STR2## R=H or C 1 -C 4 -alkyl, which is optionally be substituted by halogen, hydroxy, cyano, C 1 -C 4 -alkoxy, carboxyl, sulpho or sulphato, Z=a fiber-reactive radical of the formula ##STR3## wherein M=H, C 1 -C 4 -alkyl, C 1 -C 4 -thioalkyl, F or CF 3 , with the exception of the dyestuff of the formula ##STR4##

Bifunctional reactive dyestuffs containing vinylsulphone or alkylsulphone groups and a 2,4 difluoro pyrimidine group

Reactive dyestuffs which, as the free acid, have the following formula ##STR1## in which K is ##STR2## the bonding to the triazinyl radical taking place in each case via the amino function of K, and the remaining substituents have the meaning given in the description, are suitable in particular for the dyeing and printing of natural and synthetic OH- and/or amido-containing materials.

Azo dyestuffs containing fluorotriazinyl and vinylsulfonylmethyl-type reactive groups

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