Wolfgang Kern
Ludwig Maximilian University of Munich
652 Papers
3.9K Citations
Wolfgang Kern is an academic researcher from Ludwig Maximilian University of Munich. The author has contributed to research in topics: Myeloid leukemia & Leukemia. The author has an hindex of 80, co-authored 585 publications. Previous affiliations of Wolfgang Kern include German Cancer Research Center & University of Münster.
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Papers
FISH Analysis In 843 Cases with Myeloid Malignancies Revealed TET2 deletions In 6% of Patients Which Were Accompanied by TET2 Mutations In 51% of Cases
Claudia Haferlach,Sandra Wille,Alexander Kohlmann,Susanne Schnittger,Wolfgang Kern,Torsten Haferlach +5 more
TL;DR: An easy to perform FISH assay was developed applying BACs covering the TET2 gene and validated on samples with Tet2 deletions proven by SNP array analysis, suggesting these FISH probes were not detectable in cases with myeloid malignancies.
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Multiparameter Flow Cytometry in Patients with Suspected Myelodysplastic Syndromes Adds Significant Prognostic Information: A Study on 1,013 Patients
TL;DR: The present data indicates the diagnostic use of MFC for MDS results in independent prognostic information for cases with MDS as proven by CM, and argues in favour of diagnosing MDS not only based on a combination of CM and CG but of adding also M FC for better classification and even prognostication in the future.
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TP53 Alterations In CLL - Parameters Influencing The Prognostic Impact: A Study On 3,988 Patients
Claudia Haferlach,Frank Dicker,Sabine Jeromin,Sandra Weissmann,Andreas Roller,Wenke Worseg,Tamara Alpermann,Wolfgang Kern,Torsten Haferlach,Alexander Kohlmann,Susanne Schnittger +10 more
TL;DR: The frequency of TP53 mut and TP53 del increased significantly with age and the impact of the TP53 mutation load on survival was evaluated, while a mutation load ≥20% was significantly associated with shorter OS.
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Characterization and Quantification Of Rare BCR-ABL1 Fusion Transcripts
Susanne Schnittger,Frank Dicker,Tamara Alpermann,Christiane Eder,Annette Fasan,Simone Weber,Sabine Jeromin,Manja Meggendorfer,Wolfgang Kern,Torsten Haferlach,Claudia Haferlach +10 more
TL;DR: A detailed molecular characterization of the BCR-ABL1 rearrangement was performed and rare fusion types were detected, including one case with an additional alternative splicing event that leads to an e13a2 fusion with 19 bp insertion.
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Cracking a Nut with a Sledgehammer? – Broadening the Spectrum of Gene Mutation Analysis in MDS Does Not Add Clinically Relevant Information
Manja Meggendorfer,Wencke Walter,Niroshan Nadarajah,Claudia Haferlach,Wolfgang Kern,Torsten Haferlach +5 more
TL;DR: To determine the actual gain of genetic information with increasing NGS panel sizes, starting with small panels of diagnostic guidelines to the complete coding region (=exome) covered by whole genome sequencing (WGS).
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