Wolfgang Enard
Ludwig Maximilian University of Munich
139 Papers
371 Citations
Wolfgang Enard is an academic researcher from Ludwig Maximilian University of Munich. The author has contributed to research in topics: Biology & Gene. The author has an hindex of 44, co-authored 115 publications. Previous affiliations of Wolfgang Enard include Max Planck Society & Loyola Marymount University.
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Papers
Mouse models of human evolution
TL;DR: Together with a mouse model of a recent, still polymorphic human change, these studies allow careful optimism that at least some aspects of human evolution can be functionally studied in mice.
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Protective immune trajectories in early viral containment of non-pneumonic SARS-CoV-2 infection
Kami Pekayvaz,Alexander Leunig,Rainer Kaiser,Sophia Brambs,Markus Joppich,Aleksandar Janjic,Oliver Popp,Vivien Polewka,Lucas E. Wange,Christoph Gold,Marieluise Kirchner,Maximilian Muenchhoff,Johannes C. Hellmuth,Clemens Scherer,Tabea M. Eser,Flora Deak,Niklas Kuhl,Andreas Linder,Kathrin Saar,Lukas Tomas,Christian Schulz,Wolfgang Enard,Inge Kroidl,Christof Geldmacher,Michael von Bergwelt-Baildon,Oliver T. Keppler,Ralf Zimmer,Philipp Mertins,Norbert Huebner,Michael Hoelscher,Steffen Massberg,Konstantin Stark,Leo Nicolai +32 more
TL;DR: A protective ISG phenotype in patients with successful containment of SARS-CoV-2 infection without progression to COVID-19 is demonstrated, suggesting this early protective interferon response might be exploited as a therapeutic approach and for disease course prediction.
17
Transcriptional effects of actin-binding compounds: the cytoplasm sets the tone
Florian A. Gegenfurtner,Themistoklis Zisis,Nader Al Danaf,Waldemar Schrimpf,Zane Kliesmete,Christoph Ziegenhain,Wolfgang Enard,Uli Kazmaier,Don C. Lamb,Angelika M. Vollmar,Stefan Zahler +10 more
TL;DR: It is concluded that actin-binding compounds predominantly regulate transcription via their influence on cytoplasmatic G-actin levels, while transcriptional processes relying on intranuclear actin polymerization or functional F- actin networks are not targeted by these compounds at tolerable doses.
16
Comparative genomics of brain size evolution
TL;DR: Progress in understanding the molecular and cellular mechanisms of mammalian brain development, in genome sequencing and in genome editing, promises to make a close integration of evolutionary and experimental methods a fruitful approach to better understand the genetics of mammalian head size evolution.
Ly6D+Siglec-H+ precursors contribute to conventional dendritic cells via a Zbtb46+Ly6D+ intermediary stage
Konstantin Lutz,Andrea Musumeci,Christopher Sie,Ezgi Dursun,Elena Winheim,Johannes W. Bagnoli,Christoph Ziegenhain,Lisa Rausch,Volker Bergen,Malte D Luecken,Robert A.J. Oostendorp,Barbara U. Schraml,Fabian J. Theis,Wolfgang Enard,Thomas Korn,Anne Krug +15 more
TL;DR: In this paper , the heterogeneity and commitment of subsets in this compartment were investigated by single-cell transcriptomics and high-dimensional flow cytometry combined with cell fate analysis: within the CD11c+MHCII-/loSiglec-H+CCR9lo DC precursor pool cells expressing high levels of Ly6D and lacking expression of transcription factor Zbtb46 contain immediate pDC precursors and CCR9loB220hi immediate dendritic cells which still generate pDCs and cDCs in vitro and in vivo under steady state conditions.