Wolfgang A. Tomé

TL;DR: The Niemierko-Goitein linear-quadratic algorithm with gamma50 slope 1-3 was used and the calculated values of TCP decreased rapidly with increasing degrees of cold dose for any size of the cold spot, even as small as 1% fractional volume.

TL;DR: The study shows that the choice of a low-risk classification for the rPTV in selective boosting IMRT may lead to a significant loss in TCP and for the example considered in which normal tissue complications can be limited through the use of a tissue expander it appears that the therapeutic ratio can be improved using a functional imaging technique with a high sensitivity and limited specificity.

TL;DR: This review discusses potential strategies to mitigate the detrimental effects on neurogenesis and neurocognition resulting from cranial irradiation, and how the rationale for these strategies compares with the current outcome of pre-clinical studies.

TL;DR: The technological, physical, and radiobiological rationale for the ongoing and upcoming clinical trials that will use image-guided IMRT in the form of helical tomotherapy are reviewed; and the plans for testing the hypotheses in a rigorous prospective fashion are described.