Witold Szymański
10 Papers
Witold Szymański is an academic researcher. The author has contributed to research in topics: Chemistry & Biology. The author has an hindex of 1, co-authored 3 publications.
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Papers
Engineering a new-to-nature cascade for phosphate-dependent formate to formaldehyde conversion in vitro and in vivo
Maren Nattermann,Sebastian Wenk,Pascal Pfister,Hai-yan He,Seung Hwan Lee,Witold Szymański,N. Guntermann,Fayin Zhu,Lennart Nickel,Jan Zarzycki,Nicole Paczia,Giancarlo Franciò,Walter Leitner,Ramon Gonzalez,Tobias J. Erb +14 more
TL;DR: In this paper , a two-enzyme formate-phosphate reductase (P i )-based pathway was proposed to expand synthetic formate assimilation by suppressing cross-talk with native metabolism.
Menstrual blood-derived mesenchymal stromal cells: impact of preconditioning on the cargo of extracellular vesicles as potential therapeutics
María de Los Ángeles de Pedro,Esther López,Francisco Manuel González-Nuño,M. Pulido,V. Alvarez,Ana M. Marchena,Christian Preußer,Witold Szymański,Elke Pogge von Strandmann,Johannes Graumann,Francisco M. Sánchez-Margallo,Javier G. Casado,María Gómez-Serrano +12 more
TL;DR: Priming of MenSCs under proinflammatory and hypoxic conditions affected the cargo proteome of EVs released, resulting in different therapeutic potential, and thus warrants experimental exploration with the aim to generate better-defined MSC-derived bioproducts.
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Menstrual blood-derived mesenchymal stromal cell secretome modulates macrophage polarization in a preconditioning-dependent manner
María de Los Ángeles de Pedro,M. Pulido,Ana M. Marchena,Verónica Álvarez,Francisco Manuel González-Nuño,Witold Szymański,Johanna Pörschke,Silke Reinartz,Johannes Graumann,Elke Pogge von Strandmann,Francisco M. Sánchez-Margallo,María Gómez-Serrano +11 more
TL;DR: Menstrual blood-derived mesenchymal stromal cell secretome modulates macrophage polarization in a preconditioning-dependent manner, influencing innate immune response and cytokine gene expression, with proteomic analysis revealing key proteins associated with macrophage polarization and inflammatory response regulation.
Isolation Defines Identity: Functional Consequences of Extracellular Vesicle Purification Strategies.
C. Preußer,Dolores J Salander,Witold Szymański,Johannes Graumann,Yukai Wang,Kai Zhao,Jörg W Bartsch,María Gómez-Serrano,Daniel Bachurski,Silke Reinartz,Elke von Pogge von Strandmann +10 more
TL;DR: This study compares four EV isolation strategies, revealing that purification methods significantly impact EV composition and function, with ultracentrifugation/density gradient and tangential flow filtration/size exclusion chromatography yielding EVs with strong enzymatic activity.
Impaired Plakophilin-2 in obesity breaks cell cycle dynamics to breed adipocyte senescence
Aina Lluch,Jèssica Latorre,Angela Serena-Maione,Isabel Espadas,Estefanía Caballano-Infantes,José María Moreno-Navarrete,Núria Oliveras-Cañellas,Wifredo Ricart,María M. Malagón,Alejandro Martin-Montalvo,Walter Birchmeier,Witold Szymański,Johannes Graumann,María Gómez-Serrano,Elena Sommariva,José Manuel Fernández-Real,Francisco B. Ortega +16 more
TL;DR: It is reported here that levels of PKP2 steadily increase during fat cell differentiation, and are compromised if adipocytes are exposed to a pro-inflammatory milieu, and expression in subcutaneous adipose tissue diminishes in patients with obesity, and normalizes upon mild-to-intense weight loss.