Wim B. van den Berg
Radboud University Nijmegen
292 Papers
2.5K Citations
Wim B. van den Berg is an academic researcher from Radboud University Nijmegen. The author has contributed to research in topics: Arthritis & Inflammation. The author has an hindex of 84, co-authored 292 publications. Previous affiliations of Wim B. van den Berg include Radboud University Nijmegen Medical Centre.
Chat about Author
Papers
Gene therapy for rheumatoid arthritis. Lessons from animal models, including studies on interleukin-4, interleukin-10, and interleukin-1 receptor antagonist as potential disease modulators.
TL;DR: Evidence from animal models convincingly supports the fact that gene therapy can be an advantageous strategy in the treatment of chronic destructive RA as well as improving local gene delivery by enhanced viral infection of synovial cells, using RGD-modified adenovirus, or achieving prolonged persistence and regulated expression with AAV.
66
Interleukin-32: a predominantly intracellular proinflammatory mediator that controls cell activation and cell death.
Bas Heinhuis,Mihai G. Netea,Wim B. van den Berg,Charles A. Dinarello,Charles A. Dinarello,Leo A. B. Joosten +5 more
TL;DR: Taken into account the observed biological functions of IL-32, it may belong to a class of cytokines, like IL-1α, IL-33, and IL-37, with both intracellular and extracellular functions.
64
Amplifying elements of arthritis and joint destruction
Wim B. van den Berg,Peter L E M van Lent,Leo A. B. Joosten,Shahla Abdollahi-Roodsaz,Marije I. Koenders +4 more
TL;DR: Spontaneous T cell-dependent arthritis in IL1Ra–/– mice is absent under germ-free conditions, and markedly suppressed inTLR4-deficient mice, and TLR4 blocking with a receptor antagonist suppresses erosive arthritis.
Differential role of IL-18 and IL-12 in the host defense against disseminated Candida albicans infection.
Mihai G. Netea,Alieke G. Vonk,Mabel van den Hoven,Ineke Verschueren,Leo A. B. Joosten,Johan H. J. M. van Krieken,Wim B. van den Berg,Jos W. M. van der Meer,Bart Jan Kullberg +8 more
TL;DR: The anticandidal effects of endogenous IL‐18 are mediated late during the infection by assuring a proper IFN‐γ response and promoting the infiltration of the site of infection by monocytes.
62
The loss of α2β1 integrin suppresses joint inflammation and cartilage destruction in mouse models of rheumatoid arthritis.
Marvin A. Peters,Doreen Wendholt,Simon Strietholt,Svetlana Frank,Noreen Pundt,Adelheid Korb-Pap,Leo A. B. Joosten,Wim B. van den Berg,George Kollias,Beate Eckes,Thomas Pap +10 more
TL;DR: It is suggested that α2β1 integrin contributes significantly to inflammatory cartilage destruction by promoting fibroblast proliferation and attachment and MMP expression.
62