Wilma Chen
University of Texas at Austin
2 Papers
136 Citations
Wilma Chen is an academic researcher from University of Texas at Austin. The author has contributed to research in topics: Adenosine deaminase deficiency & Adenosine deaminase. The author has an hindex of 2, co-authored 2 publications. Previous affiliations of Wilma Chen include University of Texas Health Science Center at Houston.
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Papers
The Use of Enzyme Therapy to Regulate the Metabolic and Phenotypic Consequences of Adenosine Deaminase Deficiency in Mice: DIFFERENTIAL IMPACT ON PULMONARY AND IMMUNOLOGIC ABNORMALITIES *
Michael R. Blackburn,Melissa B. Aldrich,Jonathan B. Volmer,Wilma Chen,Hongyan Zhong,Susan J. Kelly,Michael S. Hershfield,Surjit K. Datta,Rodney E. Kellems +8 more
TL;DR: It is suggested that the pulmonary and immune phenotypes are separable and are related to the severity of metabolic disturbances in these tissues and the mechanisms underlying the immunodeficiency and pulmonary phenotypes associated with ADA deficiency.
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Impaired germinal center maturation in adenosine deaminase deficiency.
Melissa B. Aldrich,Wilma Chen,Michael R. Blackburn,Hector Martinez-Valdez,Surjit K. Datta,Rodney E. Kellems +5 more
TL;DR: Comparisons of levels of the ADA substrates, adenosine and 2′-deoxyadenosine, as well resulting dATP levels and S-adenosylhomocysteine hydrolase inhibition in bone marrow and spleen suggested that d ATP accumulation in ADA-deficient spleens may be responsible for impaired B cell development, and this hypothesis was confirmed by the profound loss of germinal center architecture.