Willy Kinzy
Novartis
11 Papers
126 Citations
Willy Kinzy is an academic researcher from Novartis. The author has contributed to research in topics: Epitope & In vivo. The author has an hindex of 10, co-authored 11 publications.
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Papers
Removal of anti-Galα1,3Gal xenoantibodies with an injectable polymer
Andreas Katopodis,Richard G. Warner,Rudolf O. Duthaler,Markus Streiff,Armin Bruelisauer,Olivier Kretz,Birgit Dorobek,Elke Persohn,Hendrik Andres,Alain Schweitzer,Gebhard Thoma,Willy Kinzy,Valérie F. J. Quesniaux,Emanuele Cozzi,Hugh F. S. Davies,Rafael Mañez,David P. White +16 more
TL;DR: It is concluded that GAS914 may be used therapeutically for the specific removal of alphaGal Ab's, a soluble trisaccharide-polylysine conjugate of approximately 500 kDa that effectively competes for alphaGal binding by alphaGal IgM and IgG in vitro.
Synthesis and Biological Evaluation of a Potent E-Selectin Antagonist
TL;DR: The efficient synthesis (10 linear steps) of the potent sLe(x) mimetic 2 is described, which shows a 30-fold improved affinity in a static, cell-free E-selectin-ligand binding assay and is predictive for the in vivo efficacy of test compounds.
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Synthesis of Gal determinant epitopes, their glycomimetic variants, and trimeric clusters—relevance to tumor associated antigens and to discordant xenografts
Stephen Hanessian,Hoan K. Huynh,Gurijala V. Reddy,Rudolph O Duthaler,Andreas Katopodis,Markus Streiff,Willy Kinzy,Reinhold Oehrlein +7 more
TL;DR: The synthesis of Galα1→3Gal-quinic acid pseudo-trisaccharides and their elaboration into trimeric clusters is described in this paper, where Galα 1→3
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Noninvasive assessment of gastric emptying by near-infrared fluorescence reflectance imaging in mice: pharmacological validation with tegaserod, cisapride, and clonidine.
Hans-Ulrich Gremlich,Vicente Martínez,Rainer Kneuer,Willy Kinzy,Eckhard Weber,Hans-Juergen Pfannkuche,Markus Rudin +6 more
TL;DR: FRI using fluorescently labeled beads allows the reliable determination of gastric emptying as well as the assessment of pharmacological interventions and offers the potential to characterize molecular targets and pathways involved in physiological regulation and pharmacological modulation of gastrics emptying.
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