The invention provides certain thiazolopyrimidine compounds of formula (I) or a pharmaceutically acceptable salt or solvate thereof; processes and intermediates used in their preparation, pharmaceutical compositions containing them and their use in therapy.

Novel thiazolo(4,5-d)pyrimidine compounds

Use of a compound of formula (I): wherein R1 is selected from alkyl, alkoxy, aryloxy, alkylthio, arylthio, aryl, halogen, CN, NR6R7, NR5COR6, NR5CONR6R7, NR5CO2R8 and NR5SO2R8; R2 is selected from heteroaryl attached via an unsaturated carbon; R3 is selected from H, alkyl, halogen, OR5, SR5 and NR6R7; R4 is selected from H, acyclic alkyl, CONR6R7, CONR5NR6R7, COR6, CO2R8 and SO2R8; R5, R6 and R7 are independently selected from H, alkyl and aryl, or where R6 and R7 are in an NR6R7 group, R6 and R7 may be linked to form a heterocyclic group, or where R5, R6 and R7 are in a (CONR5NR6R7) group, R5 and R6 may be linked to form a heterocyclic group; and R8 is selected from alkyl and aryl, or a pharmaceutically acceptable salt thereof or prodrug thereof, in the treatment or prevention of a disorder in which the blocking of purine receptors, particularly adenosine receptors and more particularly A2A receptors, may be beneficial, particularly wherein said disorder is a movement disorder such as Parkinson's disease or said disorder is depression, cognitive or memory impairment, acute or chronic pain, ADHD or narcolepsy, or for neuroprotection in a subject; compounds of formula (I) for use in therapy; and novel compounds of formula (I) per se.

Triazolo [4,5-d] pyrimidine derivatives and their use as purinergic receptor antagonists

The present invention relates to phenylcyclopropylamine derivatives. In particular, pharmaceutical compositions comprising phenylcyclopropylamine derivatives are provided. The compounds of this invention can, inter alia, be used for the treatment and the prevention of cancer as well as neurodegenerative diseases or disorders.

Phenylcyclopropylamine derivatives and their medical use

A liquid crystal display device includes a display panel and a viewing angle control panel. The viewing angle control panel includes a pair of substrates, a liquid crystal layer interposed between the pair of substrates, and a pair of electrodes for applying an electric field to the liquid crystal layer. The liquid crystal layer is composed from hybrid-aligned liquid crystal molecules. The viewing angle of the display panel is controlled by changing an alignment state of the hybrid-aligned liquid crystal molecules in the liquid crystal layer by voltage applied by the electrodes.

Viewing angle control element, method of manufacturing the same, liquid crystal display device, and electronic apparatus

The invention relates to a compound of Formula (I): (A')x-(A)-(B)-(Z)-(L)-(D), wherein: (A) is heteroaryl or aryl; each (A'), if present, is independently chosen from aryl, arylalkoxy, arylalkyl, heterocyclyl, aryloxy, halo, alkoxy, haloalkyl, cycloalkyl, haloalkoxy, and cyano, wherein each (A') is substituted with 0, 1, 2, or 3 substituents independently chosen from halo, haloalkyl, aryl, arylalkoxy, alkyl, alkoxy, cyano, sulfonyl, amido, and sulfinyl; X is 0, 1, 2, or 3; (B) is a cyclopropyl ring, wherein (A) and (Z) are covalently bonded to different carbon atoms of (B); (Z) is -NH-; (L) is chosen from -CH2CH2-, -CH2CH2CH2-, and -CH2CH2CH2CH2-; and (D) is chosen from -N(-R1)-R2, -O-R3, and -S-R3, wherein: R1 and R2 are mutually linked to form a heterocyclic ring together with the nitrogen atom that R1 and R2 are attached to, wherein said heterocyclic ring has 0, 1, 2, or 3 substituents independently chosen from -NH2, -NH(C1-C6 alkyl), -N(C1-C6 alkyl)(C1-C6 alkyl), alkyl, halo, cyano, alkoxy, haloalkyl, and haloalkoxy, or R1 and R2 are independently chosen from -H, alkyl, cycloalkyl, haloalkyl, and heterocyclyl, wherein the sum of substituents on R1 and R2 together is 0, 1, 2, or 3, and the substituents are independently chosen from -NH2, -NH(C1-C6 alkyl), -N(C1-C6 alkyl)(C1-C6 alkyl), and fluoro; and R3 is chosen from -H, alkyl, cycloalkyl, haloalkyl, and heterocyclyl, wherein R3 has 0, 1, 2, or 3 substituents independently chosen from -NH2, -NH(C1-C6 alkyl), -N(C1-C6 alkyl)(C1-C6 alkyl), and fluoro; or an enantiomer, diastereomer, or mixture thereof, or a pharmaceutically acceptable salt or solvate thereof. The compounds of the invention show inhibitory LSD1 activity, which makes them useful in the treatment or prevention of diseases such as cancer.

Lysine specific demethylase-1 inhibitors and their use

Triazolo[4,5-d]pyrimidine compounds, their use as medicaments, compositions containing them and processes for their preparation. The compounds of the invention have the formula (I) as follows: wherein R, X and R1 through R3 are as defined in the specification.

Triazolo(4,5-d)pyrimidine compounds

The invention provides certain thiazolopyrimidine compounds of general formula (I), processes and intermediates used in their preparation, pharmaceutical compositions containing them and their use in therapy.

Novel thiazolopyrimidine compounds

Compounds of the formula (I) ##STR1## wherein B is O or CH 2 ; X is selected from NR 1 R 2 , SR 1 , and C 1 -C 7 alkyl; Y is selected SR 1 , NR 1 R 2 , and C 1 -C 7 alkyl; R 1 and R 2 is each and independently selected from H, or C 1 -C 7 alkyl optionally substituted upon or within the alkyl chain by one or more of O, S, N or halogen; R 3 and R 4 are both H, or R 3 and R 4 together form a bond; A is COOH, C(O)NH(CH 2 ) p COOH, C(O)N (CH 2 ) q COOH! 2 , C(O)NHCH(COOH)(CH 2 ) r COOH, or 5-tetrazolyl, wherein p, q and r is each and independently 1, 2 or 3; as well as pharmaceutically acceptable salts and prodrugs thereof, pharmaceutical compositions comprising the novel compounds and use of the compounds in therapy. Also within the scope of the invention are novel intermediates to the novel compounds. The novel compounds are in particular useful in the prevention of platelet aggregation.

Inhibitors of platelet aggregation

The invention relates to triazolo[4,5-d]pyrimidin-3-yl derivatives of formula (I), which are useful in the treatment of platelet aggregation disorders.

Triazolo(4,5-d)pyrimidinyl derivatives and their use as medicaments

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