William Rinaldi
6 Papers
10 Citations
William Rinaldi is an academic researcher. The author has contributed to research in topics: Immune system & Virus. The author has an hindex of 3, co-authored 5 publications.
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Papers
Fetal neuropathology in zika virus-infected pregnant female rhesus monkeys
Amanda J. Martinot,Peter Abbink,Onur Afacan,Anna K. Prohl,Roderick T. Bronson,Jonathan L. Hecht,Erica N. Borducchi,Rafael A. Larocca,Rebecca Peterson,William Rinaldi,Melissa Ferguson,Peter J. Didier,Deborah E. Weiss,Mark G. Lewis,Rafael De La Barrera,Edward Yang,Simon K. Warfield,Dan H. Barouch,Dan H. Barouch +18 more
TL;DR: It is shown that infection of female rhesus monkeys early in pregnancy with Zika virus (ZIKV) recapitulates many features of CZS in humans, suggesting novel strategies to prevent and to treat this disease.
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Tetravalent Rabies-Vectored Filovirus and Lassa Fever Vaccine Induces Long-term Immunity in Nonhuman Primates
Drishya Kurup,Christine R. Fisher,Gabrielle Scher,Catherine Yankowski,AnnaMarie Testa,Rohan Keshwara,Tiago Abreu-Mota,Rachael Lambert,Melissa J. Ferguson,William Rinaldi,Leonard P. Ruiz,Christoph Wirblich,Matthias J. Schnell +12 more
TL;DR: This article evaluated the immunogenicity of adjuvanted monovalent rabies virus (RABV)-based vaccine candidates against Ebola virus (FILORAB1), Sudan virus ( FILORAB2), Marburg virus (filORAB3), Lassa virus (LASSARAB1) and combined trivalent vaccine candidate (filorAB1-3) and tetravalent candidate candidate (filmorab1-4, lassa-specific immunoglobulin G) in nonhuman primates.
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Broadly neutralizing antibodies to SARS-related viruses can be readily induced in rhesus macaques
Wan-ting He,Meng Yuan,Sean Callaghan,Rami Musharrafieh,Ge Song,Murillo Silva,Murillo Silva,Nathan Beutler,Wen-Hsin Lee,Peter Yong,Jonathan L. Torres,Mariane B. Melo,Mariane B. Melo,Panpan Zhou,Fangzhu Zhao,Xueyong Zhu,Linghang Peng,Deli Huang,Fabio Anzanello,James Ricketts,Mara Parren,Elijah Garcia,Melissa J. Ferguson,William Rinaldi,Stephen A. Rawlings,David Nemazee,Davey M. Smith,Bryan Briney,Yana Safonova,Thomas F. Rogers,Thomas F. Rogers,Shane Crotty,Shane Crotty,Shane Crotty,Darrell J. Irvine,Andrew B. Ward,Ian A. Wilson,Dennis R. Burton,Raiees Andrabi +38 more
TL;DR: This paper showed that immunization of rhesus macaques with SARS-CoV-2 spike (S) protein generates potent receptor binding domain cross-neutralizing antibody (nAb) responses to both SARS and CoV-1.
Adjuvanted Fusion Protein Vaccine Induces Durable Immunity to Onchocerca volvulus in Mice and Non-Human Primates
Nathan M. Ryan,Jessica A. Hess,Nancy Tricoche,Cheri Turner,Jenny Davis,Nikolai Petrovsky,Melissa J. Ferguson,William Rinaldi,Valerie M. Wong,Ayako Shimada,Bin Zhan,Maria Elena Bottazzi,Benjamin L. Makepeace,S. W. Gray,Darrick Carter,Sara Lustigman,David Abraham +16 more
TL;DR: In this paper , mice and non-human primates (NHPs) were immunized with a vaccine consisting of a fusion of two O. volvulus protein antigens, Ov-103 and Ov-RAL-2 (Ov-FUS-1), and three different adjuvants: Advax-CpG, alum, and AlT4.
Therapeutic efficacy of potent neutralizing HIV-1-specific monoclonal antibodies in SHIV-infected rhesus monkeys
Dan H. Barouch,James B. Whitney,Brian Moldt,Florian Klein,Thiago Y. Oliveira,Jinyan Liu,Kathryn E. Stephenson,Hui-Wen Chang,Karthik Shekhar,Sanjana Gupta,Joseph P. Nkolola,Michael S. Seaman,Kaitlin M. Smith,Erica N. Borducchi,Crystal Cabral,Jeffrey Y. Smith,Stephen Blackmore,Srisowmya Sanisetty,James R. Perry,Matthew Beck,Mark G. Lewis,William Rinaldi,Arup K. Chakraborty,Arup K. Chakraborty,Pascal Poignard,Michel C. Nussenzweig,Michel C. Nussenzweig,Dennis R. Burton,Dennis R. Burton +28 more
TL;DR: A profound therapeutic effect of potent neutralizing HIV-1-specific monoclonal antibodies in SHIV-infected rhesus monkeys as well as an impact on host immune responses are demonstrated.