William R. Henderson
University of British Columbia
75 Papers
744 Citations
William R. Henderson is an academic researcher from University of British Columbia. The author has contributed to research in topics: Medicine & Intensive care. The author has an hindex of 29, co-authored 74 publications. Previous affiliations of William R. Henderson include Vancouver Coastal Health & Royal Columbian Hospital.
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Papers
Intensive versus conventional glucose control in critically ill patients.
Nice-Sugar Study Investigators,Dean R. Chittock,Steve Su,D. Blair,Denise Foster,Rinaldo Bellomo,Deborah J. Cook,Vinay Dhingra,Peter Dodek,Paul C. Hébert,William R. Henderson,Stephane Heritier,Daren K. Heyland,Colin McArthur,Ellen McDonald,Imogen Mitchell,Robyn Norton,J. Potter,Bruce G. Robinson,Juan J. Ronco +19 more
TL;DR: In this large, international, randomized trial, it was found that intensive glucose control increased mortality among adults in the ICU: a blood glucose target of 180 mg or less per deciliter resulted in lower mortality than did a target of 81 to 108 mg perDeciliter.
Intensive insulin therapy and mortality among critically ill patients: a meta-analysis including NICE-SUGAR study data
Donald E. G. Griesdale,Russell J. de Souza,Rob M. van Dam,Daren K. Heyland,Deborah J. Cook,Atul Malhotra,Rupinder Dhaliwal,William R. Henderson,Dean R. Chittock,Simon Finfer,Daniel Talmor +10 more
TL;DR: Intensive insulin therapy significantly increased the risk of hypoglycemia and conferred no overall mortality benefit among critically ill patients, but this therapy may be beneficial to patients admitted to a surgical ICU.
Hypoglycemia and risk of death in critically ill patients.
Simon Finfer,Bette Liu,Dean R. Chittock,Robyn Norton,John Myburgh,Colin McArthur,Imogen Mitchell,Denise Foster,Vinay Dhingra,William R. Henderson,Juan J. Ronco,Rinaldo Bellomo,Deborah J. Cook,Ellen McDonald,Peter Dodek,Paul C. Hébert,Daren K. Heyland,Bruce G. Robinson +17 more
TL;DR: In critically ill patients, intensive glucose control leads to moderate and severe hypoglycemia, both of which are associated with an increased risk of death, and the association exhibits a dose-response relationship and is strongest for death from distributive shock.
968
•Journal Article
Roles of cysteinyl leukotrienes in airway inflammation, smooth muscle function, and remodeling. Discussion
Stephen T. Holgate,Marc Peters-Golden,Reynold A. Panettieri,William R. Henderson,Hans Bisgoard,Stephen T. Holgate,Anthony P. Sampson,Bill Henderson,Reynold Panettieri +8 more
TL;DR: Evidence from a mouse model of asthma demonstrated that CysLT(1) receptor antagonists inhibit the airway remodeling processes, including eos inophil trafficking to the lungs, eosinophil degranulation, T(H)2 cytokine release, mucus gland hyperplasia, smooth muscle, myofibroblasts, and airway fibrosis.
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Pathogenesis, prevalence, diagnosis, and management of exercise-induced bronchoconstriction: a practice parameter
John M. Weiler,Sandra D. Anderson,Christopher Randolph,Sergio Bonini,Timothy J. Craig,David S. Pearlman,Kenneth W. Rundell,William S. Silvers,William W. Storms,David I. Bernstein,Joann Blessing-Moore,Linda Cox,David A. Khan,David M. Lang,Richard A. Nicklas,John Oppenheimer,Jay M. Portnoy,Diane E. Schuller,Sheldon L. Spector,Stephen A. Tilles,Dana Wallace,William R. Henderson,Lawrence B. Schwartz,David Kaufman,Talal M Nsouli,Lawrence Shieken,Nelson Rosario +26 more
TL;DR: This systematic review and meta-analyses show clear trends in prognosis for asthma patients using a simple, straightforward, and scalable approach that combines e-mail, telephone, and laboratory testing.