William N. Beavers
Vanderbilt University
18 Papers
40 Citations
William N. Beavers is an academic researcher from Vanderbilt University. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 8, co-authored 9 publications.
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Papers
Methylglyoxal-derived posttranslational arginine modifications are abundant histone marks
James J. Galligan,James A. Wepy,Matthew D. Streeter,Philip J. Kingsley,Michelle M. Mitchener,Orrette R. Wauchope,William N. Beavers,Kristie L. Rose,Tina Wang,David Spiegel,Lawrence J. Marnett +10 more
TL;DR: The existence of Lys and Arg modifications on histones derived from a glycolytic by-product, methylglyoxal (MGO), demonstrate the existence of a previously undetected histone modification and provide a link between cellular metabolism and the histone code.
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Stable histone adduction by 4-oxo-2-nonenal: a potential link between oxidative stress and epigenetics.
James J. Galligan,Kristie L. Rose,William N. Beavers,Salisha Hill,Keri A. Tallman,William P. Tansey,Lawrence J. Marnett +6 more
TL;DR: In this paper, the authors describe histones as major targets for modification by 4-oxo-2-nonenal, resulting in a stable Lys modification structurally analogous to other histone Lys acylations.
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Alkylation Damage by Lipid Electrophiles Targets Functional Protein Systems
Simona G. Codreanu,Jody C. Ullery,Jing Zhu,Keri A. Tallman,William N. Beavers,Ned A. Porter,Lawrence J. Marnett,Bing Zhang,Daniel C. Liebler +8 more
TL;DR: Damage occurred selectively across functional protein interaction networks, with the most highly alkylation-susceptible proteins mapping to networks involved in cytoskeletal regulation and being alkylated only at electrophile concentrations that caused significant toxicity.
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Zn-regulated GTPase metalloprotein activator 1 modulates vertebrate zinc homeostasis
Andy Weiss,Caitlin C. Murdoch,Katherine A. Edmonds,Matthew R. Jordan,Andrew J. Monteith,Y. Randika Perera,Aslin M. Rodríguez Nassif,Amber M. Petoletti,William N. Beavers,Matthew J. Munneke,Sydney Drury,Evan S. Krystofiak,Kishore Thalluri,Hongwei Wu,Angela Kruse,Richard D. DiMarchi,Richard M. Caprioli,Jeffrey M. Spraggins,Walter J. Chazin,David P. Giedroc,Eric P. Skaar +20 more
TL;DR: In this article , the Zn-regulated GTPase metalloprotein activator (ZNG1) family has been found to have an important role for intracellular Zn trafficking.
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Elevated transferrin receptor impairs T cell metabolism and function in systemic lupus erythematosus
Kelsey Voss,Allison E. Sewell,Evan S. Krystofiak,Katherine N. Gibson-Corley,Arissa Young,Jacob Halum Basham,Ayaka Sugiura,Emily N. Arner,William N. Beavers,Dillon E. Kunkle,Megan E. Dickson,Gabriel A. Needle,Eric P. Skaar,W. Kimryn Rathmell,Michelle J. Ormseth,Amy S. Major,Jeffrey C. Rathmell +16 more
TL;DR: In this article , the transferrin receptor (CD71) was identified as differentially critical for TH1 and inhibitory for induced regulatory T cells (iTregs) in systemic lupus erythematosus (SLE).
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