William Lopez

TL;DR: Data suggest that intra- and inter-subunit electrostatic networks at the extracellular entrance of the hCx26 pore play critical roles in hemichannel gating reactions, and a role of these residues in stabilization of the open state is suggested.

TL;DR: A novel two-electrode voltage clamp (TEVC)/dye uptake assay is developed that allows the analysis of how human mutations causing diseases affect kinetic properties and permselectivity of molecular signaling and enables the study of molecular mechanisms, including selectivity and saturability, associated with molecular transport in large-pore channels.

TL;DR: Connexin hemichannels may mediate physiological glutathione release in diverse cell types and maleimide-based modification is the more appropriate approach to perform chemical modification to study structure-function of connexin channels, and other channels and transporters that are permeable to large molecules, such as pannex in channels.