William Johnston
8 Papers
25 Citations
William Johnston is an academic researcher. The author has contributed to research in topics: Lung cancer & Cell therapy. The author has an hindex of 4, co-authored 8 publications.
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Papers
Pharmacokinetic Profile of Inhaled Submicron Particle Paclitaxel (NanoPac®) in a Rodent Model.
James Verco,William Johnston,Michael Baltezor,Philip J. Kuehl,Andrew P. Gigliotti,Steven A. Belinsky,Anita Lopez,Ronald Wolff,Lauren Hylle,Gere S. diZerega +9 more
TL;DR: In the rodent model, inhaled NanoPac demonstrated substantial deposition and retention of paclitaxel in sampled lung tissue and resulted in an order of magnitude increase in dose-normalized pulmonary exposure over IVnP.
23
Inhaled Submicron Particle Paclitaxel (NanoPac) Induces Tumor Regression and Immune Cell Infiltration in an Orthotopic Athymic Nude Rat Model of Non-Small Cell Lung Cancer
James Verco,William Johnston,Michael V Frost,Michael Baltezor,Philip J. Kuehl,Anita Lopez,Andrew P. Gigliotti,Steven A. Belinsky,Ronald Wolff,Gere S. diZerega +9 more
TL;DR: Tumor regression and immune cell infiltration were observed in all treatment groups, with an increased incidence noted in animals receiving IH submicron particle paclitaxel treatment.
13
Patent
Methods for Treating Lung Disorders
Michael Baltezor,Matthew Mcclorey,William Johnston,Gere S. diZerega,James Verco +4 more
- 13 Jun 2018
TL;DR: In this paper, compositions and methods for treating lung disorders including lung tumors by pulmonary administration of compositions comprising taxane particles such as docetaxel or paclitaxel particles are presented.
4
NanoPac inhalation treatment of NSCLC in a nude rat orthotopic lung cancer model.
TL;DR: NanoPac is sub micronized paclitaxel in stable powder form without coating or carrier agents and microscopically indistinguishable from non-treated controls in a previous PK study on healthy male rats.
1
Patent
Methods for Isolating Tumor-Specific Immune Cells from a Subject for Adoptive Cell Therapy and Cancer Vaccines
Gere S. diZerega,Holly Maulhardt,Michael Baltezor,Sam Campbell,Charles J. Decedue,William Johnston,Matthew Mcclorey,James Verco +7 more
- 05 Dec 2019
TL;DR: In this article, methods for the isolation of tumor-specific immune cells from subjects that have a malignant tumor and have received local administration of a composition comprising taxane particles to the tumor, and use of such isolated immune cells in compositions for adoptive cell therapy and cancer vaccines.