William J. Greenlee
Merck & Co.
331 Papers
5.6K Citations
William J. Greenlee is an academic researcher from Merck & Co.. The author has contributed to research in topics: Angiotensin II & Chemistry. The author has an hindex of 52, co-authored 326 publications. Previous affiliations of William J. Greenlee include Schering-Plough & United States Military Academy.
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Papers
Oximino-piperidino-piperidine-based CCR5 antagonists. Part 2: synthesis, SAR and biological evaluation of symmetrical heteroaryl carboxamides.
Anandan Palani,Sherry Shapiro,John W. Clader,William J. Greenlee,Vice Susan F,Stuart W. McCombie,Kathleen Cox,Julie M. Strizki,Bahige M. Baroudy +8 more
TL;DR: A series of potent and orally bioavailable CCR5 antagonists containing symmetrical 2,6-Dimethyl isonicotinamides and 2, 6-dimethyl pyrimidines amides were generated with enhanced affinity for the CCR 5 receptor.
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Chapter 7. Anglotensln / Renln Modulators
TL;DR: This chapter summarizes the recent drug discovery and development of non-peptidic angiotensin II (AII) receptor antagonists in the renin-angiotens in system area.
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Patent
Angiotensin II antagonists incorporating an indole or dihydroindole
Scott W. Bagley,William J. Greenlee,Daljit S. Dhanoa,Arthur A. Patchett +3 more
- 07 Apr 1992
TL;DR: There are substituted indoles and dihydroindoles of Formula I which are useful as angiotensin II antagonists as mentioned in this paper, but they are not suitable for Formula II.
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Potent imidazole angiotensinII antagonists: acyl sulfonamides and acyl sulfamides as tetrazole replacements
Elizabeth M. Naylor,Prasun K. Chakravarty,Prasun K. Chakravarty,Colleen A. Costello,Colleen A. Costello,Raymond S.L. Chang,Raymond S.L. Chang,Tsing-Bau Chen,Tsing-Bau Chen,Kristie A. Faust,Kristie A. Faust,Victor J. Lotti,Victor J. Lotti,Salah D. Kivlighn,Salah D. Kivlighn,Gloria J. Zingaro,Gloria J. Zingaro,Peter K. S. Siegl,Peter K. S. Siegl,Pancras C. Wong,Pancras C. Wong,David J. Carini,David J. Carini,Ruth R. Wexler,Ruth R. Wexler,Arthur A. Patchett,Arthur A. Patchett,William J. Greenlee,William J. Greenlee +28 more
TL;DR: AT1 binding affinities for these potent AII antagonists were similar to their tetrazole analogs, and an enhancement in AT2 potencies was observed, particularly with acyl sulfonamides or sulfamides bearing hydrophobic substituents.
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Patent
Substituted fused pyrimidinones
Stephen E. de Laszlo,Eric E. Allen,William J. Greenlee,Arthur A. Patchett +3 more
- 05 Mar 1992
TL;DR: In this paper, the substituted fused pyrimidinones of formula (I) were used as angiotensin II antagonists, which are useful as angio-drugs.
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