William H. Wong
6 Papers
William H. Wong is an academic researcher. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 1, co-authored 4 publications.
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Papers
Small intestine and colon tissue-resident memory CD8+ T cells exhibit molecular heterogeneity and differential dependence on Eomes.
Yun Hsuan Lin,Han G. Duong,Abigail E. Limary,Eleanor S. Kim,Paul Hsu,Shefali Patel,William H. Wong,Cynthia Indralingam,Yi Liu,Priscilla Yao,Natalie R. Chiang,Sara Vandenburgh,Taylor R. Anderson,Jocelyn G. Olvera,Amir Ferry,Kennidy K Takehara,Wenhao Jin,Matthew S. Tsai,Gene W. Yeo,Ananda W. Goldrath +19 more
TL;DR: In this paper , the T-box transcription factor Eomes, which represses TRM cell formation in some tissues, exhibited unexpected context-specific regulatory roles in supporting the maintenance of established TRM cells in the small intestine, but not in the colon.
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Identification of CD8+ T-Cell–Immune Cell Communications in Ileal Crohn's Disease
Han G. Duong,Eunice J Choi,Paul Hsu,Natalie R. Chiang,Shefali Patel,Jocelyn G. Olvera,Yi Liu,Yun Hsuan Lin,Priscilla Yao,William H. Wong,Cynthia Indralingam,Matthew S. Tsai,Brigid S. Boland,Wei Wang +13 more
TL;DR: In this article , the authors applied a previously published computational approach, NicheNet, to predict immune cell types interacting with CD8+ T-cell subsets, revealing putative ligand-receptor pairs and key transcriptional changes downstream of these cell-cell communications.
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Functional Diversity of Memory CD8 T Cells is Spatiotemporally Imprinted
Miguel Reina-Campos,Alexander Monell,Amir Ferry,Vida Luna,Kitty P. Cheung,Giovanni Galletti,Nicole E. Scharping,Kennidy K Takehara,Sara Quon,Brigid Boland,Yun Hsuan Elena Lin,William H. Wong,Cynthia Indralingam,Gene W. Yeo,John T. Chang,Maximilian Heeg,Ananda Goldrath +16 more
TL;DR: The spatiotemporal imprint of memory CD8 T cell functional diversity in the small intestine is characterized by distinct transcriptional programs and spatial segregation of subpopulations.
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Regulation of CD8 T Cell Differentiation by the RNA-Binding Protein DDX5.
Tiani L. Louis,William H. Wong,Priscilla Yao,Nadia S. Kurd,Tiffani Tysl,Cynthia Indralingam,Shengyun Ma,Wendy Huang +7 more
TL;DR: The RNA-binding protein DEAD-box protein 5 (DDX5) is a polyfunctional regulator of gene expression, but its role in CD8+ T cell biology has not been extensively investigated as mentioned in this paper .
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Foxo1 regulates intestinal tissue-resident memory CD8 T cell biology in an anatomic compartment- and context-specific manner.
Paul Hsu,William H. Wong,Yun Hsuan Lin,Sara Vandenburgh,Yi Chia Liu,Priscilla Yao,Cynthia Indralingam,Gene W Yeo,Elina I Zúñiga,Ananda W. Goldrath,Wei Wang,John T Chang +11 more