William H. Hildebrand
University of Oklahoma Health Sciences Center
203 Papers
2.6K Citations
William H. Hildebrand is an academic researcher from University of Oklahoma Health Sciences Center. The author has contributed to research in topics: Human leukocyte antigen & Epitope. The author has an hindex of 49, co-authored 195 publications. Previous affiliations of William H. Hildebrand include Texas Tech University Health Sciences Center & Southern Illinois University Carbondale.
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Papers
Antigen presentation and interferon signatures in B cells driven by localized ablative cancer immunotherapy correlate with extended survival
Kaili Liu,Ashley R. Hoover,Jason R. Krawic,Christa I. DeVette,Xiaohui Sun,William H. Hildebrand,Mark L. Lang,Robert L. Axtell,Wei Chen +8 more
TL;DR: The findings show that the combination of local ablation and local application of immunostimulant initiates the activation of interferon signatures and antigen-presentation in B cells which is associated with positive clinical outcomes for breast cancer.
16
Human Herpesvirus 7 U21 Tetramerizes To Associate with Class I Major Histocompatibility Complex Molecules
Nathan A. May,Qiuhong Wang,Andrea Balbo,Sheryl L. Konrad,Rico Buchli,William H. Hildebrand,Peter Schuck,Amy W. Hudson +7 more
TL;DR: The U21 gene product from human herpesvirus 7 binds to and redirects class I major histocompatibility complex (MHC) molecules to a lysosomal compartment, suggesting that U21 does not require additional cellular proteins to interact with class I MHC molecules.
16
A novel T-cell receptor mimic defines dendritic cells that present an immunodominant West Nile virus epitope in mice.
Sojung Kim,Amelia K. Pinto,Nancy B. Myers,Oriana E. Hawkins,Krysten L. Doll,Saghar Kaabinejadian,Jason Netland,Michael J. Bevan,Jon A. Weidanz,William H. Hildebrand,Michael S. Diamond,Ted H. Hansen +11 more
TL;DR: It is shown that in vivo the 10‐mer was presented on the surface of uninfected and infected CD8α+CD11c+ dendritic cells, which suggests the use of direct and cross‐presentation pathways.
15
Dengue virus-infected human dendritic cells reveal hierarchies of naturally expressed novel NS3 CD8 T cell epitopes
Paolo Piazza,Diana M. Campbell,Ernesto T. A. Marques,William H. Hildebrand,R. Buchli,Robbie B. Mailliard,Charles R. Rinaldo +6 more
TL;DR: A hierarchy ranking based on magnitude and polyfunctionality of the antigen‐specific response showed that dominant epitopes were both highly conserved and cross‐reactive against multiple DENV serotypes.
14
Identification of class I HLA T cell control epitopes for West Nile virus.
Saghar Kaabinejadian,Paolo Piazza,Curtis McMurtrey,Stephen Vernon,Steven Cate,Wilfried Bardet,Fredda Schafer,Kenneth W. Jackson,Diana M. Campbell,Rico Buchli,Charles R. Rinaldo,William H. Hildebrand +11 more
TL;DR: Comparative mass spectroscopy was applied to determine the number of WNV peptides presented by the HLA-A*11:01 of infected cells after which T cell responses to these HLA/WNV complexes were assessed, demonstrating that class I HLA reduce the WNV polyprotein to a handful of immune targets and that polyfunctional T cells recognize infections by zeroing in on particular HLA /WNV epitopes.