William G. Devine
Boston University
21 Papers
33 Citations
William G. Devine is an academic researcher from Boston University. The author has contributed to research in topics: Biology & Translation (biology). The author has an hindex of 13, co-authored 20 publications. Previous affiliations of William G. Devine include Northeastern University & University of Connecticut.
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Papers
Protozoan Parasite Growth Inhibitors Discovered by Cross-Screening Yield Potent Scaffolds for Lead Discovery
William G. Devine,Jennifer L. Woodring,Uma Swaminathan,Emanuele Amata,Gautam Patel,Jessey Erath,Norma Roncal,Patricia J. Lee,Susan E. Leed,Ana Rodriguez,Kojo Mensa-Wilmot,Richard J. Sciotti,Michael P. Pollastri +12 more
TL;DR: Based on hits identified in this screening campaign, the preparation of several replacements for the quinazoline scaffold are described and these inhibitors’ biological activities against these parasites are reported.
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Amidino-Rocaglates: A Potent Class of eIF4A Inhibitors
Jennifer Chu,Wenhan Zhang,Regina Cencic,William G. Devine,Dmitri Beglov,Thomas Henkel,Lauren E. Brown,Sandor Vajda,John A. Porco,Jerry Pelletier +9 more
TL;DR: The RNA clamping activity of >200 unique rocaglate derivatives is explored and a potent class of synthetic rocagelates called amidino-rocaglates is reported on, among the most potent rocAGlates documented to date.
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Probing the energy efficiency of microwave heating and continuous-flow conventional heating as tools for organic chemistry
TL;DR: In this paper, the energy efficiency of using microwave heating has been compared with batch and continuous-flow conventional heating for three reactions, and the results show that the two methods are comparable in their energy consumption.
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Inhibition of translation initiation factor eIF4a inactivates heat shock factor 1 (HSF1) and exerts anti-leukemia activity in AML.
Yuki Nishida,Ran Zhao,Lauren Heese,Hiroki Akiyama,Shreya Patel,Alex M. Jaeger,Rodrigo Jacamo,Kensuke Kojima,Kensuke Kojima,Man Chun John Ma,Vivian Ruvolo,Dhruv Chachad,William G. Devine,Susan Lindquist,R. Eric Davis,John A. Porco,Luke Whitesell,Luke Whitesell,Michael Andreeff,Jo Ishizawa +19 more
TL;DR: In this article, the eIF4A inhibition by the potent and specific compound rohinitib (RHT) inactivated HSF1 in these cells, and exerted pronounced in vitro and in vivo anti-leukemia effects against progenitor and leukemia-initiating cells, especially those with FLT3-internal tandem duplication (ITD).
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Antiparasitic Lead Discovery: Toward Optimization of a Chemotype with Activity Against Multiple Protozoan Parasites.
William G. Devine,Sarah M. Thomas,Jessey Erath,Kelly A. Bachovchin,Patricia J. Lee,Susan E. Leed,Ana Rodriguez,Richard J. Sciotti,Kojo Mensa-Wilmot,Michael P. Pollastri +9 more
TL;DR: A library of analogues with improved calculated physicochemical properties built on the quinoline scaffold of 3 incorporating small, polar aminoheterocycles in place of the 4-(3-fluorobenzyloxy)aniline substituent with biological activity against Trypanosoma brucei, Chagas disease, and leishmaniasis.
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