A biometric monitoring device is used to determine a user's heart rate by using a heartbeat waveform sensor and a motion detecting sensor. In some embodiments, the device collects collecting concurrent output data from the heartbeat waveform sensor and output data from the motion detecting sensor, detects a periodic component of the output data from the motion detecting sensor, and uses the periodic component of the output data from the motion detecting sensor to remove a corresponding periodic component from the output data from the heartbeat waveform sensor. From this result, the device may determine and present the user's heart rate.

Wearable heart rate monitor

The invention provides systems, including apparatus, methods, and kits, for the microfluidic manipulation and/or detection of particles, such as cells and/or beads. The invention provides systems, including apparatus, methods, and kits, for the microfluidic manipulation and/or analysis of particles, such as cells, viruses, organelles, beads, and/or vesicles. The invention also provides microfluidic mechanisms for carrying out these manipulations and analyses. These mechanisms may enable controlled input, movement/positioning, retention/localization, treatment, measurement, release, and/or output of particles. Furthermore, these mechanisms may be combined in any suitable order and/or employed for any suitable number of times within a system. Accordingly, these combinations may allow particles to be sorted, cultured, mixed, treated, and/or assayed, among others, as single particles, mixed groups of particles, arrays of particles, heterogeneous particle sets, and/or homogeneous particle sets, among others, in series and/or in parallel. In addition, these combinations may enable microfluidic systems to be reused. Furthermore, these combinations may allow the response of particles to treatment to be measured on a shorter time scale than was previously possible. Therefore, systems of the invention may allow a broad range of cell and particle assays, such as drug screens, cell characterizations, research studies, and/or clinical analyses, among others, to be scaled down to microfluidic size. Such scaled-down assays may use less sample and reagent, may be less labor intensive, and/or may be more informative than comparable macrofluidic assays.

Microfluidic particle-analysis systems

A variety of elastomeric-based microfluidic devices and methods for using and manufacturing such devices are provided. Certain of the devices have arrays of reaction sites to facilitate high throughput analyses. Some devices also include reaction sites located at the end of blind channels at which reagents have been previously deposited during manufacture. The reagents become suspended once sample is introduced into the reaction site. The devices can be utilized with a variety of heating devices and thus can be used in a variety of analyses requiring temperature control, including thermocycling applications such as nucleic acid amplification reactions, genotyping and gene expression analyses.

Microfluidic device and methods of using same

Methods and apparatus for implementing microfluidic analysis devices are provided. A monolithic elastomer membrane associated with an integrated pneumatic manifold allows the placement and actuation of a variety of fluid control structures, such as structures for pumping, isolating, mixing, routing, merging, splitting, preparing, and storing volumes of fluid. The fluid control structures can be used to implement a variety of sample introduction, preparation, processing, and storage techniques.

/pdf/fluid-control-structures-in-microfluidic-devices-2yu0k9t17b.pdf

Fluid control structures in microfluidic devices

An intravascular device for measuring blood pressure and flow is disclosed, which includes an elongate shaft having a pressure transducer and a flow transducer connected to its distal end. The pressure transducer may be a ferrofluid-type pressure transducer and the flow transducer may be an anemometer-type flow transducer. Measurement circuitry is also disclosed which provides a means for simultaneous measurement of both blood pressure and blood flow parameters. A sensor shield may be employed to isolate radial blood flow which is indicative of turbulent blood flow. An alternative blood flow measurement device is also disclosed which utilizes a thin metal film anemometer to measure flow in a vascular lumen.

Intravascular pressure and flow sensor

Devices, systems, and methods for processing sample materials. The sample materials may be located in a plurality of process chambers in the device, which is rotated during heating of the sample materials.

Enhanced sample processing devices, systems and methods

Methods and devices for thermal processing of multiple samples at the same time are disclosed. The sample processing devices provide process arrays that include conduits useful in distributing sample materials to a group pf process chambers located in fluid communication with the main conduits. The sample processing devices may include one or more of the following features in various combinations: deformable seals, process chambers connected to the main conduit by feeder conduits exiting the main conduit at offset locations, U-shaped loading chambers, and a combination of melt bonded and adhesively bonded areas.

Sample processing devices

A biomedical sensor system. The system can include a sensor adapted to create a signal based on a physiological characteristic from a subject, and a hub adapted to receive the signal from the sensor. The signal can include at least one of an electromagnetic signal, an electrical signal, an acoustic signal, a mechanical signal, a thermal signal, and a chemical signal. The system can further include a connector adapted to couple the sensor and the hub, the connector having a variable length, such that the sensor and the hub can be positioned a variable distance apart by changing the length of the connector. The connector can be adapted to provide a pathway between the sensor and the hub for the signal. A method of applying a biomedical sensor system to a subject can include changing the length of the variable-length connector to provide an appropriate distance between the sensor and the hub, and coupling the sensor to the subject.

Biomedical Sensor System

Methods and devices for thermal processing of multiple samples at the same time are disclosed. The assemblies include carriers and sample processing devices with process arrays that include conduits useful in distributing sample materials to a group pf process chambers located in fluid communication with the main conduits. The sample processing devices may include one or more of the following features in various combinations: deformable seals, process chambers connected to the main conduit by feeder conduits exiting the main conduit at offset locations, U-shaped loading chambers, and a combination of melt bonded and adhesively bonded areas. The carriers may be used to apply selective compression to the sample processing devices.

Sample processing devices and carriers

The present invention provides methods and devices for distributing sample material to a plurality of process chambers (50) in a sample processing device (10) by rotating the device about an axis of rotation. The process chambers are located along conduits(40) extending from a loading chamber and, together, the loading chamber, conduits, and process chambers form process arrays that are aligned along a length of the sample processing devices. The process arrays are unvented, i.e., access to the interior volume of the process arrays is available only through the loading chamber. Also disclosed are methods of centrifugally loading sample material into the process chambers, as well as an assembly including a sample processing device and a carrier.

Centrifugal filling of sample processing devices

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