William A. Held
Roswell Park Cancer Institute
50 Papers
857 Citations
William A. Held is an academic researcher from Roswell Park Cancer Institute. The author has contributed to research in topics: DNA methylation & Methylation. The author has an hindex of 32, co-authored 50 publications.
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Papers
Aberrant CpG-island methylation has non-random and tumour-type-specific patterns.
Joseph F. Costello,Joseph F. Costello,Michael C. Frühwald,Michael C. Frühwald,Dominic J. Smiraglia,Laura J. Rush,Gavin P. Robertson,Xin Gao,Fred A. Wright,Jamison D. Feramisco,Päivi Peltomäki,James C. Lang,David E. Schuller,Li Yu,Clara D. Bloomfield,Michael A. Caligiuri,Allan J. Yates,Ryo Nishikawa,H.-J. Su Huang,Nicholas J. Petrelli,Xueli Zhang,M. S. O'Dorisio,William A. Held,Webster K. Cavenee,Webster K. Cavenee,Christoph Plass +25 more
TL;DR: This report reports a global analysis of the methylation status of 1,184 unselected CpG islands in each of 98 primary human tumours using restriction landmark genomic scanning (RLGS), and estimates that an average of 600 C pG islands were aberrantly methylated in the tumours, including early stage tumours.
1.5K
Association of tissue-specific differentially methylated regions (TDMs) with differential gene expression.
Fei Song,Joseph F. Smith,Makoto T. Kimura,Arlene D. Morrow,Tomoki Matsuyama,Hiroki Nagase,William A. Held +6 more
TL;DR: Analysis of 14 TDMs by methylation-specific PCR and by bisulfite genomic sequencing confirms that the regions identified by RLGS are differentially methylated in a tissue-specific manner, disputing the general notion that all CpG islands are unmethylated.
366
Excessive CpG island hypermethylation in cancer cell lines versus primary human malignancies
Dominic J. Smiraglia,Laura J. Rush,Michael C. Frühwald,Michael C. Frühwald,Zunyan Dai,William A. Held,Joseph F. Costello,James C. Lang,Charis Eng,Bin Li,Fred A. Wright,Michael A. Caligiuri,Christoph Plass +12 more
TL;DR: Data indicate that most CpG island hypermethylation observed in cancer cell lines is due to an intrinsic property of cell lines as opposed to the malignant tissue from which they originated.
The gene family for major urinary proteins: Expression in several secretory tissues of the mouse
TL;DR: Significant levels of MUP mRNA are found in several secretory tissues of the mouse: the liver and the submaxillary, lachrymal and mammary glands, where each tissue appears to express a characteristic pattern of Mup mRNAs.
197
Targeting a Complex Transcriptome: The Construction of the Mouse Full-Length cDNA Encyclopedia
Piero Carninci,Kazunori Waki,Toshiyuki Shiraki,Hideaki Konno,Kazuhiro Shibata,Masayoshi Itoh,Katsunori Aizawa,Takahiro Arakawa,Yoshiyuki Ishii,Daisuke Sasaki,Hidemasa Bono,Shinji Kondo,Yuichi Sugahara,Rintaro Saito,Naoki Osato,Shiro Fukuda,Kenjiro Sato,Akira Watahiki,Tomoko Hirozane-Kishikawa,Mari M. Nakamura,Yuko Shibata,Ayako Yasunishi,Noriko Kikuchi,Atsushi Yoshiki,Moriaki Kusakabe,Stefano Gustincich,Kirk W. Beisel,William J. Pavan,Vassilis Aidinis,Akira Nakagawara,William A. Held,Hiroo Iwata,Tomohiro Kono,Hiromitsu Nakauchi,Paul A. Lyons,Christine A. Wells,David A. Hume,Michela Fagiolini,Takao K. Hensch,Michelle L. Brinkmeier,Sally A. Camper,Junji Hirota,Peter Mombaerts,Masami Muramatsu,Yasushi Okazaki,Jun Kawai,Yoshihide Hayashizaki,Yoshihide Hayashizaki +47 more
TL;DR: High coverage explains discrepancies between the very large numbers of clusters (and TUs) of this project, which also include non-protein-coding RNAs, and the lower gene number estimation of genome annotations.