Wilhelm Ehrlich
Robert Koch Institute
21 Papers
185 Citations
Wilhelm Ehrlich is an academic researcher from Robert Koch Institute. The author has contributed to research in topics: Nicotinamide & Arthritis. The author has an hindex of 8, co-authored 21 publications.
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Papers
Inhibition of the induction of collagenase by interleukin-1 beta in cultured rabbit synovial fibroblasts after treatment with the poly(ADP-ribose)-polymerase inhibitor 3-aminobenzamide.
TL;DR: It is concluded that poly(ADP-ribosyl)ation plays a role in the induction of the expression of collagenase and that 3-aminobenzamide can inhibit this process.
44
Protection from acetaminophen-induced liver damage by the synergistic action of low doses of the poly(ADP-ribose) polymerase-inhibitor nicotinamide and the antioxidant N-acetylcysteine or the amino acid l-methionine
TL;DR: The hepatoprotective effects of inhibitors of NAD-dependent adenoribosylation reactions and of antioxidants in analgesic-induced hepatic injury are investigated and a combination of both nicotinamide and N-acetylcysteine results in a complete protection from acetaminophen-induced release of GOT and GPT from injured liver cells.
34
Intracellular metabolism of 4-hydroxynonenal in primary cultures of rabbit synovial fibroblasts.
TL;DR: An involvement of synovial fibroblasts in the secondary antioxidant defense system of the joints during conditions of higher HNE concentrations like rheumatoid arthritis is suggested.
27
The influence of antagonists of poly(adp-ribose) metabolism on acetaminophen hepatotoxicity
TL;DR: The main application of inhibitors of adenoribosylation reactions as for the combinational use in pharmaceutical preparations of analgesics and antirheumatic drugs in order to avoid hepatic damage is seen.
20
Inhibition of poly(ADP-ribose) formation by 4-hydroxynonenal in primary cultures of rabbit synovial fibroblasts.
TL;DR: The molecular basis of HNE-mediated effects on cell proliferation, differentiation and transformation might be due to the inhibitory effect of poly(ADP-ribos)ylation.
13