Wesley Hung
University of Toronto
12 Papers
75 Citations
Wesley Hung is an academic researcher from University of Toronto. The author has contributed to research in topics: Synapse & Pannexin. The author has an hindex of 9, co-authored 12 publications. Previous affiliations of Wesley Hung include Mount Sinai Hospital, Toronto & Lunenfeld-Tanenbaum Research Institute.
Chat about Author
Papers
An SCF-like ubiquitin ligase complex that controls presynaptic differentiation
TL;DR: This work reports the identification of FSN-1, a novel F-box protein that is required in presynaptic neurons for the restriction and/or maturation of synapses in Caenorhabditis elegans and provides evidence that T10H9.2, which encodes the C. elegans receptor tyrosine kinase ALK (anaplastic lymphoma kinase), may be a target or a downstream effector through which FSN
240
Neuronal polarity is regulated by a direct interaction between a scaffolding protein, Neurabin, and a presynaptic SAD-1 kinase in Caenorhabditis elegans.
TL;DR: It is proposed that Neurabin functions as a scaffold to facilitate SAD-1-mediated phosphorylation for substrates specific for restricting axonal fate during neuronal polarization.
Altered p27Kip1 Phosphorylation, Localization, and Function in Human Epithelial Cells Resistant to Transforming Growth Factor β-Mediated G1 Arrest
Sandra Ciarallo,Venkateswaran Subramaniam,Wesley Hung,Jin hwa Lee,Rouslan Kotchetkov,Charanjit Sandhu,Andrea Milic,Joyce M. Slingerland +7 more
TL;DR: Investigations in a human mammary epithelial cell (HMEC) model suggest a model in which TGF-β modulates p27 phosphorylation from its cyclin D1-bound assembly phosphoform to an alternate form that binds tightly to inhibit cyclin E1-cdk2.
64
C. elegans STRADα and SAD cooperatively regulate neuronal polarity and synaptic organization
TL;DR: It is proposed that STRD-1 establishes neuronal polarity and organizes synaptic proteins in a complex with the SAD-1 kinase, and STRADα and LKB1 regulate neuronal development through multiple effectors that are shared in some cellular contexts but distinct in others.
47
A Co-operative Regulation of Neuronal Excitability by UNC-7 Innexin and NCA/NALCN Leak Channel
Magali Bouhours,Michelle D. Po,Michelle D. Po,Shangbang Gao,Wesley Hung,Hang Li,John Georgiou,John C. Roder,John C. Roder,Mei Zhen,Mei Zhen +10 more
TL;DR: It is proposed that, in addition to gap junction-mediated functions, UNC-7 innexin may also form hemichannels to regulate C. elegans' neuronal activity cooperatively with the NCA family leak channels.