Wesley Hung
Lunenfeld-Tanenbaum Research Institute
13 Papers
9 Citations
Wesley Hung is an academic researcher from Lunenfeld-Tanenbaum Research Institute. The author has contributed to research in topics: Ubiquitin ligase & Motor neuron. The author has an hindex of 6, co-authored 13 publications.
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Papers
An Upconversion Nanoparticle Enables Near Infrared-Optogenetic Manipulation of the Caenorhabditis elegans Motor Circuit.
Yanxiao Ao,Kanghua Zeng,Bin Yu,Yu Miao,Wesley Hung,Zhongzheng Yu,Yanhong Xue,Timothy Thatt Yang Tan,Tao Xu,Tao Xu,Mei Zhen,Xiangliang Yang,Yan Zhang,Shangbang Gao +13 more
TL;DR: In this paper, a lanthanide-doped upconversion nanoparticle (UCNP) was used to activate inhibitory GABAergic motor neurons, leading to reduced action potential firing in the body wall muscle and resulting in locomotion inhibition.
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Natural sensory context drives diverse brain-wide activity during C. elegans mating
Vladislav Susoy,Wesley Hung,Daniel Witvliet,Joshua E. Whitener,Min Wu,Brett J. Graham,Mei Zhen,Vivek Venkatachalam,Vivek Venkatachalam,Aravinthan D. T. Samuel +9 more
TL;DR: From the contribution of individual neurons to circuits, this study shows how diverse brain-wide dynamics emerge from the integration of sensory perception and motor actions within their natural context.
The UBR-1 ubiquitin ligase regulates glutamate metabolism to generate coordinated motor pattern in Caenorhabditis elegans.
Jyothsna Chitturi,Jyothsna Chitturi,Wesley Hung,Anas M. Abdel Rahman,Min Wu,Min Wu,Maria A. Lim,John A. Calarco,Renee Baran,Xun Huang,James W. Dennis,James W. Dennis,Mei Zhen,Mei Zhen +13 more
TL;DR: It is found that the functional loss of C. elegans UBR-1 leads to a specific motor deficit: when adult animals generate reversal movements, A-class motor neurons exhibit synchronized activation, preventing body bending and raising an intriguing possibility that UBR proteins regulate glutamate metabolism, which is critical for neuronal development and signaling.
Excitatory Motor Neurons are Local Central Pattern Generators in an Anatomically Compressed Motor Circuit for Reverse Locomotion [preprint]
Shangbang Gao,Sihui Asuka Guan,Anthony D. Fouad,Jun Meng,Yung-Chi Huang,Yi Li,Salvador Alcaire,Wesley Hung,Taizo Kawano,Yangning Lu,Yingchuan Billy Qi,Yishi Jin,Mark J. Alkema,Christopher Fang-Yen,Mei Zhen +14 more
TL;DR: It is shown that the cholinergic and excitatory class A motor neurons exhibit intrinsic and oscillatory activity, and such an activity can drive reverse locomotion without premotor interneurons.
A Neuroendocrine Modulation to Sustain C. elegans Forward Locomotion
Maria A. Lim,Jyothsna Chitturi,Valeriya Laskova,Jun Meng,Daniel Findeis,Anne Wiekenberg,Ben Mulcahy,Linjiao Luo,Yan Li,Yangning Lu,Wesley Hung,Yixin Qu,Chi-Yip Ho,Douglas Holmyard,Ni Ji,Rebecca WcWhirter,Aravinthan D. T. Samuel,David M. Miller,Ralf Schnabel,John A. Calarco,Mei Zhen +20 more
TL;DR: The role of a neuroendocrine cell RID in sustaining a specific behavioral state in C. elegans is established, and the Six/SO-family homeobox transcription factor UNC-39 governs lineage-specific neurogenesis to give rise to a neuron RID.
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