Werner Fürst
University of Bonn
8 Papers
208 Citations
Werner Fürst is an academic researcher from University of Bonn. The author has contributed to research in topics: Activator (genetics) & Sphingolipid Activator Proteins. The author has an hindex of 7, co-authored 8 publications.
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Papers
Activator proteins and topology of lysosomal sphingolipid catabolism.
Werner Fürst,Konrad Sandhoff +1 more
TL;DR: This review summarizes the information available on the structure, function, biosynthesis, gene organization and pathobiochemistry of the known sphingolipid activator proteins and offers models for their mode of action and for the topology of lysosomal digestion of glycolipids.
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The human GM2 activator protein. A substrate specific cofactor of beta-hexosaminidase A.
TL;DR: Studies on the enzymic degradation of GM2 derivatives with modifications in the ceramide portion indicate that mainly steric hindrance by adjacent lipid molecules impedes the access of Hex A to membrane-bound GM2 (whose degradation therefore depends on solubilization by the GM2 activator) and in addition that the interaction between the GM3 activator complex and the enzyme must be highly specific.
115
The precursor of sulfatide activator protein is processed to three different proteins.
TL;DR: It seems that three different proteins are derived from the sulfatide activator precursor by proteolytic processing, as possible processing sites were found on the precursor at sites adjacent to the N- termini and C-termini of the mature proteins.
114
The complete amino-acid sequences of human ganglioside GM2 activator protein and cerebroside sulfate activator protein
TL;DR: The complete amino-acid sequences of human ganglioside GM2 activatorprotein and cerebroside sulfate activator protein have been established by Edman degradation and show no sequence or structural similarities.
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The organization of the gene for the human cerebroside sulfate activator protein
TL;DR: The organization of 14 exons covering 97% of the cDNA sequence of human cerebroside sulfate activator protein precursor has been determined from two overlapping EMBL‐4 human genomic clones extending over 17kb.
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