Werner Apt
University of Chile
107 Papers
929 Citations
Werner Apt is an academic researcher from University of Chile. The author has contributed to research in topics: Chagas disease & Trypanosoma cruzi. The author has an hindex of 23, co-authored 106 publications.
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Papers
Benznidazole and Posaconazole in Eliminating Parasites in Asymptomatic T. Cruzi Carriers: The STOP-CHAGAS Trial
Carlos A. Morillo,Hetty Waskin,Sergio Sosa-Estani,Maria del Carmen Bangher,Carlos Cuneo,Rodolfo Milesi,Marcelo Mallagray,Werner Apt,Juan Beloscar,Joaquim Gascon,Israel Molina,Luis E. Echeverría,Hugo Colombo,José A. Pérez-Molina,Fernando Wyss,Brandi Meeks,Laura R. Bonilla,Peggy Gao,Bo Wei,Michael P. McCarthy,Salim Yusuf,Stop-Chagas Investigators +21 more
TL;DR: Posaconazole demonstrated trypanostatic activity during treatment, but it is ineffective long-term in asymptomatic T. cruzi carriers, and benznidazole monotherapy is superior to posaconazoles, with high RT-PCR conversion rates sustained at 1 year.
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Treatment of Human Chronic Fascioliasis with Triclabendazole: Drug Efficacy and Serologic Response
Werner Apt,Ximena Aguilera,F Vega,Miranda C,Inés Zulantay,Carlos A. Pérez,Melvyn Gabor,Patricia Apt +7 more
TL;DR: Between November 1990 and March 1992, 24 asymptomatic individuals in Chile with chronic hepatic fascioliasis confirmed by the presence of Fasciola hepatica eggs in feces were treated with a single oral dose of triclabendazole after an overnight fast, finding it to be the drug of choice for chronic human fasCIoliasis.
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Current and developing therapeutic agents in the treatment of Chagas disease.
TL;DR: There is no criterion of cure for chronic cases since in the majority, the serology remains positive, although it may decrease, and in congenital cases, 100% cure is obtained if the treatment is performed during the first year of life.
Human infection by Pseudoterranova decipiens (Nematoda, Anisakidae) in Chile: report of seven cases
TL;DR: From 1997 to 1999, seven human cases of infection by fourth stage larvae of Pseudoterranova decipiens in Chile were identified; all identified larvae were coughed up by the patients.
Itraconazole or allopurinol in the treatment of chronic American trypanosomiasis: the regression and prevention of electrocardiographic abnormalities during 9 years of follow-up.
TL;DR: Although itraconazole and allopurinol are equally effective at reversing ECG alterations, itrasonazole offers better protection against the development of new ECG abnormalities among those with chronic Chagas disease.
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