A wide variety of conditions can lead to loss of anatomical or functional integrity of the urinary bladder. Such conditions include various maldevelopments, comprising congenital anomalies, trauma, iatrogenic injuries, infections, inflammation, etc. Current methods for genitourinary reconstruction necessitate the use of non-urological tissues because of the limited availability of the urological tissues when damaged. Other organ systems that have been used for these purposes include buccal mucosa, skin grafts and various gastrointestinal segments. However, when such donor tissues are incorporated into the urinary tract, several complications can occur, including neuromechanical, storage and contraction changes, electrolyte abnormalities, altered drug metabolism, osteomalacia, recurrent infections, calculi formation, altered sensorium, malignancies, and complications related to increased perioperative morbidity [1]. Despite all these potential complications, the use of various gastrointestinal segments is still considered the reference standard for genitourinary reconstruction for many decades.

Biocompatible materials for bladder substitution.

One-year outcome of bladder augmentation with a novel biodegradable matrix in a porcine model

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One-year outcome of bladder augmentation with a novel biodegradable matrix in a porcine model