62 Papers
155 Citations
Wenwen Yu is an academic researcher from Tianjin Medical University Cancer Institute and Hospital. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 20, co-authored 40 publications. Previous affiliations of Wenwen Yu include Tianjin Medical University.
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Papers
Neurotensin/IL-8 pathway orchestrates local inflammatory response and tumor invasion by inducing M2 polarization of Tumor-Associated macrophages and epithelial-mesenchymal transition of hepatocellular carcinoma cells
Pei Xiao,Xinxin Long,Lijie Zhang,Yingnan Ye,Jin-Cheng Guo,Pengpeng Liu,Rui Zhang,Junya Ning,Wenwen Yu,Feng Wei,Jinpu Yu +10 more
TL;DR: HCC-derived IL-8 promoted a pro-oncogenic inflammatory microenvironment by inducing M2-type TAMs and indirectly promoting EMT, which might be a valuable therapeutic target to prevent tumor progression.
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Cancer exosome-derived miR-9 and miR-181a promote the development of early-stage MDSCs via interfering with SOCS3 and PIAS3 respectively in breast cancer.
Mengmeng Jiang,Wenwen Zhang,Rui Zhang,Pengpeng Liu,Yingnan Ye,Wenwen Yu,Xiaojing Guo,Jinpu Yu +7 more
TL;DR: Investigation of the posttranscriptional regulation mediated by cancer exosome-derived miRNAs affected the JAK/STAT signaling pathway and the development of eMDSCs indicated that tumor exosomes-derivedmiR-9 and miR-181a promoted the expansion of e MDSCs which might provide potential therapeutic target for IL-6 high breast cancer treatment.
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Interleukin-6 Trans -Signaling Pathway Promotes Immunosuppressive Myeloid-Derived Suppressor Cells via Suppression of Suppressor of Cytokine Signaling 3 in Breast Cancer.
Mengmeng Jiang,Jieying Chen,Wenwen Zhang,Rui Zhang,Yingnan Ye,Pengpeng Liu,Wenwen Yu,Feng Wei,Xiubao Ren,Jinpu Yu +9 more
TL;DR: IL-6-induced SOCS3 dysfunction and sustained activation of the JAK/STAT signaling pathway promoted the amplification and immunosuppressive function of breast cancer MDSCs in vitro and in vivo, and thus blocking the IL-6 signaling pathway is a promising therapeutic strategy for eliminating and inhibiting M DSCs to improve prognosis.
A novel MDSC-induced PD-1-PD-L1+ B-cell subset in breast tumor microenvironment possesses immuno-suppressive properties.
Meng Shen,Jian Wang,Wenwen Yu,Chen Zhang,Min Liu,Kaiyuan Wang,Lili Yang,Feng Wei,Shizhen Emily Wang,Qian Sun,Xiubao Ren +10 more
TL;DR: It is shown that in 4T1 breast cancer mice, a significantly increased number of MDSCs are accumulated when compared to normal mice, and a novel kind of Bregs with a specific phenotype PD-1−PD-L1+CD19+, which exert the greatest suppressive effects on T cells are identified.
Imbalance of TGF-β1/BMP-7 pathways induced by M2-polarized macrophages promotes hepatocellular carcinoma aggressiveness.
Junya Ning,Yingnan Ye,Dechao Bu,Gang Zhao,Tianqiang Song,Pengpeng Liu,Wenwen Yu,Hailong Wang,Hui Li,Xiubao Ren,Guoguang Ying,Yi Zhao,Jinpu Yu +12 more
TL;DR: It is proposed that the imbalance of TGF-β1/BMP-7 pathways is a feasible prognostic biomarker and recovering the imbalance might be a potential therapeutic strategy for HCC.
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