Wenjun Li
Peking University
17 Papers
2 Citations
Wenjun Li is an academic researcher from Peking University. The author has contributed to research in topics: Chemistry & Cancer. The author has an hindex of 8, co-authored 17 publications.
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Papers
An In-tether Chiral Center Modulates the Helicity, Cell Permeability, and Target Binding Affinity of a Peptide.
Kuan Hu,Hao Geng,Qingzhou Zhang,Qisong Liu,Mingsheng Xie,Chengjie Sun,Wenjun Li,Huacan Lin,Fan Jiang,Tao Wang,Yun-Dong Wu,Zigang Li +11 more
TL;DR: The addition of a precisely positioned chiral center in the tether of a constrained peptide is reported, yielding two separable peptide diastereomers with significantly different helicity, as supported by circular dichroism (CD) and NMR spectroscopy.
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Organosilicon modification to enhance the stability of black phosphorus nanosheets under ambient conditions
Jianing Zhang,Si Chen,Yue Ma,Dongyuan Wang,Jian Zhang,Yanding Wang,Wenjun Li,Zhiqiang Yu,Han Zhang,Feng Yin,Zigang Li +10 more
TL;DR: This study is the first evidence that bare BP can coordinate with organosilicon to generate the more stable TMSCl@BP, which could maintain its surface morphology and properties for 24 h under ambient conditions and has no cytotoxicity at a concentration of 200 ppm.
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A siRNA-induced peptide co-assembly system as a peptide-based siRNA nanocarrier for cancer therapy
Wenjun Li,Dongyuan Wang,Xiaodong Shi,Jingxu Li,Yue Ma,Yanding Wang,Tingting Li,Jianing Zhang,Rongtong Zhao,Zhiqiang Yu,Feng Yin,Zigang Li +11 more
TL;DR: A unique siRNA-induced peptide co-assembly nanocarrier is reported, which could efficiently co-assemble upon the addition of siRNA, forming nanospheres with high biocompatibility and transfection efficiency both in vitro and in vivo.
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Universal DNA detection realized by peptide based carbon nanotube biosensors
Wenjun Li,Yubo Gao,Jiaona Zhang,Xiaofang Wang,Feng Yin,Zigang Li,Min Zhang +6 more
- 18 Feb 2020
TL;DR: This is the first report on the utilization of a peptide as a sensing element in the design of CNT based DNA biosensors, which enables highly efficient universal DNA detection.
Peptide-Aptamer Coassembly Nanocarrier for Cancer Therapy.
TL;DR: This unique peptide-based aptamer nanocarrier showed significantly improved cell penetration and antiproliferation effect with high biocompatibility toward various cancer cell lines.
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