Wenjun Guo
8 Papers
Wenjun Guo is an academic researcher. The author has contributed to research in topics: Cancer research & Medicine. The author has an hindex of 2, co-authored 6 publications.
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Papers
MLL3 loss drives metastasis by promoting a hybrid epithelial–mesenchymal transition state
Jihong Cui,Chi Zhang,Ji-Eun Lee,Boris Bartholdy,Dapeng Yang,Yu Liu,Piril Erler,Phillip M. Galbo,Dayle Q. Hodge,Danwei Huangfu,Deyou Zheng,Kai Ge,Wenjun Guo +12 more
TL;DR: Deletion of the epigenetic regulator MLL3, a tumour suppressor frequently altered in human cancer, promoted the acquisition of hybrid EMT in breast cancer cells and enhanced metastatic capacity through increased IFNγ signalling.
33
TMZ Magnetic Temperature-sensitive Liposomes-mediated Magnetothermal Chemotherapy Induces Pyroptosis in Glioblastoma.
Jing-Jing Yao,Xinyu Feng,Xinyu Dai,Gang Peng,Zhirui Guo,Zhengxiao Liu,Min Wang,Wenjun Guo,Feng Zhang,Yuntao Li +9 more
- 01 Mar 2022
TL;DR: The research found TMZ/Fe-TSL exposed to alternating magnetic field (AMF) could induce significantly GBM cells death and promote the production of ROS and ROS showed that the expression of NLRP3, CASP1 and N-GSDMD was upregulated compared to the control group, while theexpression of CASP3 showed a reverse change.
32
A SOX9-B7x axis safeguards dedifferentiated tumor cells from immune surveillance to drive breast cancer progression.
Yu Liu,Peter John,Kenta Nishitani,Jihong Cui,Christopher D. Nishimura,John R. Christin,Nicole Couturier,Xiaoxin Ren,Yao Wei,Marc C. Pulanco,Phillip M. Galbo,Xusheng Zhang,Wenyan Fu,Wei Cui,Boris A. Bartholdy,Deyou Zheng,Gregoire Lauvau,Susan A. Fineberg,Maja H. Oktay,Xingxing Zang,Wenjun Guo +20 more
TL;DR: It is shown that the lineage-plasticity regulator SOX9, which is upregulated in dedifferentiated tumor cells, limits the number of infiltrating T lymphocytes in premalignant lesions of mouse basal-like breast cancer.
7
Targeting ABCA12-controlled ceramide homeostasis inhibits breast cancer stem cell function and chemoresistance
Jihong Cui,John R. Christin,Julie A. Reisz,Francesca Cendali,Rahul Sanawar,Marcelo Coutinho de Miranda,Angelo D’Alessandro,Wenjun Guo +7 more
TL;DR: A stem cell factor SOX9-based reporter is developed for isolating CSCs in primary tumors and metastases of spontaneous mammary tumor models and identifies a CSC-suppressing lipid metabolism pathway that can be exploited to inhibit CSC's and overcome chemoresistance.
5
Abstract B009: A SOX9-B7x axis safeguards dedifferentiated tumor cells from immunosurveillance to enable DCIS progression
TL;DR: Liu et al. as discussed by the authors showed that SOX9 was necessary for limiting infiltrating T lymphocytes to protect dedifferentiated cells from immune surveillance in premalignant lesions of basal-like breast cancer.