Rapid detection of Listeria monocytogenes in food by biofunctionalized magnetic nanoparticle based on nuclear magnetic resonance

The emergence of nanotechnology has created unprecedented hopes for addressing several unmet industrial and clinical issues, including the growing threat so-termed "antibiotic resistance" in medicine. Over the last decade, nanotechnologies have demonstrated promising applications in the identification, discrimination, and removal of a wide range of pathogens. Here, recent insights into the field of bacterial nanotechnology are examined that can substantially improve the fundamental understanding of nanoparticle and bacteria interactions. A wide range of developed nanotechnology-based approaches for bacterial detection and removal together with biofilm eradication are summarized. The challenging effects of nanotechnologies on beneficial bacteria in the human body and environment and the mechanisms of bacterial resistance to nanotherapeutics are also reviewed.

https://onlinelibrary.wiley.com/doi/pdf/10.1002/advs.202100556

Nanotechnology for Targeted Detection and Removal of Bacteria: Opportunities and Challenges.

Early detection and easy continuous monitoring of emerging or re-emerging infectious, contagious or other diseases are of particular interest for controlling healthcare advances and developing effective medical treatments to reduce the high global cost burden of diseases in the backdrop of lack of awareness regarding advancing diseases. Under an ever-increasing demand for biosensor design reliability for early stage recognition of infectious agents or contagious diseases and potential proteins, nanoscale manufacturing designs had developed effective nanodynamic sensing assays and compact wearable devices. Dynamic developments of biosensor technology are also vital to detect and monitor advanced diseases, such as human immunodeficiency virus (HIV), hepatitis B virus (HBV), hepatitis C virus (HCV), diabetes, cancers, liver diseases, cardiovascular diseases (CVDs), tuberculosis, and central nervous system (CNS) disorders. In particular, nanoscale biosensor designs have indispensable contribution to improvement of health concerns by early detection of disease, monitoring ecological and therapeutic agents, and maintaining high safety level in food and cosmetics. This review reports an overview of biosensor designs and their feasibility for early investigation, detection, and quantitative determination of many advanced diseases. Biosensor strategies are highlighted to demonstrate the influence of nanocompact and lightweight designs on accurate analyses and inexpensive sensing assays. To date, the effective and foremost developments in various nanodynamic designs associated with simple analytical facilities and procedures remain challenging. Given the wide evolution of biosensor market requirements and the growing demand in the creation of early stage and real-time monitoring assays, precise output signals, and easy-to-wear and self-regulating analyses of diseases, innovations in biosensor designs based on novel fabrication of nanostructured platforms with active surface functionalities would produce ​remarkable biosensor devices. This review offers evidence for researchers and inventors to focus on biosensor challenge and improve fabrication of nanobiosensors to revolutionize consumer and healthcare markets.

Nanoscale dynamic chemical, biological sensor material designs for control monitoring and early detection of advanced diseases.

Magnetic nanoparticles have emerged as a powerful tool for magnetic resonance imaging, biodetection, drug delivery, and hyperthermia. This review focuses on the biological detection of magnetic nanoparticles as well as their physicochemical properties. Substantial progress in the sensitivity of detection has been made by developing variety of methods. Five applications of magnetic nanoparticles in biological detection are discussed in this review: magnetic separation, magnetic sensing, magnetic manipulation, magnetic catalysis, and signal enhancer for surface plasmon resonance (SPR). Finally, some future trends and perspectives in these research areas are outlined.

/pdf/recent-advances-in-biological-detection-with-magnetic-4f868x48ui.pdf

Recent advances in biological detection with magnetic nanoparticles as a useful tool

Multi-functional lanthanide coordination polymers for multi-modal detection of nitroaromatics and trace water in organic solvents.

With current concerns of the global threat from tuberculosis, it has become important to rapidly identify the bacteria. Traditional technologies involving isolation and amplification of the pathogenic bacteria are complicated and time-consuming. In this work, we describe a sensitive NMR-based detection method to identify bacteria via bacteria-induced self-assembly of magnetic nanoparticles. Bacillus Calmette-Guerin (BCG) was used as a surrogate for Mycobacterium tuberculosis. We prepared the probes by covalent immobilization of the anti-BCG monoclonal antibody onto carboxylic acid-functionalized magnetic nanoparticles. Once a solution containing BCG was introduced, the probes switched from a well dispersed state to an aggregated one, leading to a distinct and dose-dependent change in the spin–spin relaxation time (T2) of the solution. Thus the qualitative and quantitative detection method for BCG was established. The method provides specific detection of as few as 8 bacterial cells per millilitre in experimental samples within 1 hour, which will be promising for rapid detection ofM. tuberculosis in clinical samples.

Magnetic nanosensors for highly sensitive and selective detection of bacillus Calmette-Guérin

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Magnetic nanosensors for highly sensitive and selective detection of bacillus Calmette-Guérin