Wenjie Sun
Wuhan University
18 Papers
Wenjie Sun is an academic researcher from Wuhan University. The author has contributed to research in topics: Lung cancer & MAPK/ERK pathway. The author has an hindex of 6, co-authored 18 publications.
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Papers
Recent Progress of Nanoscale Metal-Organic Frameworks in Cancer Theranostics and the Challenges of Their Clinical Application.
Wenjie Sun,Shuying Li,Guiliang Tang,Yuan Luo,Shijing Ma,Shaoxing Sun,Jiangbo Ren,Yan Gong,Conghua Xie +8 more
TL;DR: This review summarized the recent research advances on the application of NMOFs in biomedical imaging and cancer treatments in the last few years and highlighted the current challenges that impeding their translation to clinical practices.
Small Nucleolar RNA 71A Promotes Lung Cancer Cell Proliferation, Migration and Invasion via MAPK/ERK Pathway.
Guiliang Tang,Zihang Zeng,Wenjie Sun,Shuying Li,Chengcheng You,Fang Tang,Shan Peng,Shijing Ma,Yuan Luo,Jieyu Xu,Xiaoli Tian,Nannan Zhang,Yan Gong,Conghua Xie +13 more
TL;DR: SNORA71A functions as an oncogene in NSCLC and may serve as a therapeutic target and promising prognostic biomarker of NSCLCs and downregulated SNORA 71A decreased the phosphorylation of MEK and ERK1/2 in the MAPK/ERK signal pathway.
Hollow PtCo alloy nanospheres as a high-Z and oxygen generating nanozyme for radiotherapy enhancement in non-small cell lung cancer
Shuying Li,Wenjie Sun,Yuan Luo,Yanping Gao,Xueping Jiang,Cheng Yuan,Linzhi Han,Kuo Cao,Yan Gong,Conghua Xie +9 more
TL;DR: In this article, a hollow PtCo nanosphere (PtCo NS)-based novel radiosensitizer with three advantages to sensitize tumor radiotherapy was proposed, such as the high-Z element Pt ensured higher radiation absorption to cause more DNA damage, the platinum and cobalt (Co) elements exhibited a dual catalase-like enzymatic activity to convert endogenic H2O2 to O2 efficiently, and the unique hollow nature of the PtCo NS provided a large specific surface area, which could amplify the catalytic reaction of H2 O2 to induce
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Downregulation of Nitric Oxide Collaborated with Radiotherapy to Promote Anti-Tumor Immune Response via Inducing CD8+ T Cell Infiltration.
Jieyu Xu,Yuan Luo,Cheng Yuan,Linzhi Han,Qiuji Wu,Liexi Xu,Yuke Gao,Yingming Sun,Shijing Ma,Guiliang Tang,Shuying Li,Wenjie Sun,Yan Gong,Conghua Xie +13 more
TL;DR: Radiotherapy and iNOS inhibition by 1400W collaboratively suppressed tumor growth and increased survival time, as well as increased tumor-infiltrating CD8+ T cells and specific inflammatory cytokine levels, in both lung and breast cancer cells in vivo.
The prognostic value of tumor mutational burden and immune cell infiltration in esophageal cancer patients with or without radiotherapy.
Cheng Yuan,Liyang Xiang,Kuo Cao,Jianguo Zhang,Yuan Luo,Wenjie Sun,Nannan Zhang,Jiangbo Ren,Junhong Zhang,Yan Gong,Conghua Xie +10 more
- 12 Mar 2020
TL;DR: The results suggested TMB as a prognostic marker for EC patients, especially for patients who did not receive radiotherapy, whose prognosis was significantly poorer than that of TMB-L patients, which might result from the different regulatory T cell infiltration.