Wendy Dubois
National Institutes of Health
41 Papers
254 Citations
Wendy Dubois is an academic researcher from National Institutes of Health. The author has contributed to research in topics: PI3K/AKT/mTOR pathway & Biology. The author has an hindex of 22, co-authored 39 publications.
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Papers
Regulation of MicroRNA Expression and Abundance during Lymphopoiesis
Stefan Kuchen,Wolfgang Resch,Arito Yamane,Nan Kuo,Zhiyu Li,Tirtha Chakraborty,Lai Wei,Arian Laurence,Tomoharu Yasuda,Siying Peng,Jane Hu-Li,Kristina T. Lu,Wendy Dubois,Yoshiaki Kitamura,Nicolas Charles,Hong-Wei Sun,Stefan A. Muljo,Pamela L. Schwartzberg,William E. Paul,John J. O'Shea,Klaus Rajewsky,Rafael Casellas +21 more
TL;DR: This work shows that lymphocyte-specific miRNAs are either tightly controlled by polycomb group-mediated H3K27me3 or maintained in a semi-activated epigenetic state prior to full expression.
351
Distinct Regulatory Mechanisms and Functions for p53-Activated and p53-Repressed DNA Damage Response Genes in Embryonic Stem Cells
TL;DR: A whole-genome study of p53-mediated DNA damage signaling in mouse ES cells supports a model where, in response to DNA damage, p53 affects the status of ES cells through activating differentiation-associated genes and repressing ES cell-enriched genes.
284
Myc Regulates Chromatin Decompaction and Nuclear Architecture during B Cell Activation.
Kyong-Rim Kieffer-Kwon,Keisuke Nimura,Suhas S.P. Rao,Suhas S.P. Rao,Jianliang Xu,Seolkyoung Jung,Aleksandra Pekowska,Marei Dose,Evan Stevens,Ewy Mathé,Peng Dong,Su Chen Huang,Maria Aurelia Ricci,Laura Baranello,Ying Zheng,Francesco Tomassoni Ardori,Wolfgang Resch,Diana A. Stavreva,Steevenson Nelson,Michael J. McAndrew,Adriel Casellas,Elizabeth H. Finn,Charles Gregory,Brian Glenn St Hilaire,Steven M. Johnson,Wendy Dubois,Maria Pia Cosma,Eric Batchelor,David Levens,Robert D. Phair,Tom Misteli,Lino Tessarollo,Gordon L. Hager,Melike Lakadamyali,Zhe Liu,Monique Floer,Hari Shroff,Erez Lieberman Aiden,Rafael Casellas +38 more
TL;DR: The nature and transcriptional impact of chromatin decondensation is defined and an unexpected role for Myc is revealed in the establishment of nuclear topology in mammalian cells.
194
Efficiency alleles of the Pctr1 modifier locus for plasmacytoma susceptibility.
Shuling-L. Zhang,Wendy Dubois,Edward S. Ramsay,Valeri Bliskovski,Herbert C. Morse,Leki Taddesse-Heath,William C. Vass,Ronald A. DePinho,Beverly A. Mock +8 more
TL;DR: It is proposed that the BALB/c susceptibility/modifier locus is an “efficiency” allele of the p16INK4a gene, which is less active than its DBA/2 counterpart in inducing growth arrest of mouse plasmacytoma cell lines and preventing ras-induced transformation of NIH 3T3 cells.
80
mTORC1 and mTORC2 differentially regulate homeostasis of neoplastic and non-neoplastic human mast cells
Daniel Smrž,Mi-Sun Kim,Shuling Zhang,Beverly A. Mock,Šárka Smržová,Wendy Dubois,Olga Simakova,Irina Maric,Todd M. Wilson,Dean D. Metcalfe,Alasdair M. Gilfillan +10 more
TL;DR: Findings provide a rationale for adopting a targeted approaching selectively inhibiting mTORC2 to effectively reduce the proliferation of mast cells associated with inflammation and disorders of mast cell proliferation while leaving normal differentiated mast cells largely unaffected.
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