Wenbin Yang
Northwestern University
12 Papers
6 Citations
Wenbin Yang is an academic researcher from Northwestern University. The author has contributed to research in topics: Pelvic pain & Acyloxyacyl hydrolase. The author has an hindex of 6, co-authored 12 publications.
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Papers
Stool-based biomarkers of interstitial cystitis/bladder pain syndrome
Andrea Braundmeier-Fleming,Nate Russell,Wenbin Yang,Megan Y. Nas,Ryan E. Yaggie,Matthew Berry,Laurie Bachrach,Sarah C. Flury,Darlene S. Marko,Colleen Bushell,Michael Welge,Bryan A. White,Anthony J. Schaeffer,David J. Klumpp +13 more
TL;DR: Stool metabolomic studies identified glyceraldehyde as significantly elevated in IC and metabolic pathway analysis identified lipid pathways, consistent with predicted metagenome functionality, suggest that DIPP species and metabolites may serve as candidates for novel IC biomarkers in stool.
Acyloxyacyl hydrolase modulates depressive-like behaviors through aryl hydrocarbon receptor
TL;DR: It is reported that acyloxyacyl hydrolase,encoded by Aoah, is expressed in the PVN, and Aoah regulates Crf through the aryl hydrocarbon receptor (AhR), demonstrating that Aoah is a novel genetic regulator of Crf mediated through AhR, and AhR is a therapeutic target for depression.
A MAPP Network study: overexpression of tumor necrosis factor-α in mouse urothelium mimics interstitial cystitis.
TL;DR: UPII-TNF mice are a model for characterizing mechanisms of interstitial cystitis symptoms and evaluating therapies and display significant pelvic pain, voiding dysfunction, urothelial lesions, and sensory input.
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Acyloxyacyl hydrolase modulates pelvic pain severity
Wenbin Yang,Ryan E. Yaggie,M. C. Jiang,Charles N. Rudick,Joseph D. Done,Charles J. Heckman,John M. Rosen,Anthony J. Schaeffer,David J. Klumpp +8 more
TL;DR: Findings indicate that AOAH modulates pelvic pain severity, suggesting that allelic variation in Aoah influences pelvic pain in IC, and identify a polymorphism on chromosome 13, rs6314295, significantly associated with allodynia.
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Acyloxyacyl hydrolase is a host determinant of gut microbiome-mediated pelvic pain.
Afrida Rahman-Enyart,Wenbin Yang,Ryan E. Yaggie,Bryan A. White,Michael Welge,Loretta Auvil,Matthew Berry,Colleen Bushell,John M. Rosen,John M. Rosen,Charles N. Rudick,Anthony J. Schaeffer,David J. Klumpp +12 more
TL;DR: In this paper, the locus encoding acyloxyacyl hydrolase, Aoah, was identified as a modulator of pelvic pain severity in a murine IC/BPS model.
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