Wen Ying Chen
The Chinese University of Hong Kong
7 Papers
72 Citations
Wen Ying Chen is an academic researcher from The Chinese University of Hong Kong. The author has contributed to research in topics: Cystic fibrosis transmembrane conductance regulator & Capacitation. The author has an hindex of 5, co-authored 7 publications. Previous affiliations of Wen Ying Chen include Peking Union Medical College.
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Papers
The cystic fibrosis transmembrane conductance regulator in reproductive health and disease
Hsiao Chang Chan,Ye Chun Ruan,Qiong He,Min Hui Chen,Hui Chen,Wen Ming Xu,Wen Ying Chen,Chen Xie,Xiao Hu Zhang,Zhen Zhou +9 more
TL;DR: The evidence presented is consistent with an important role of CFTR in reproductive health and disease, suggesting that CFTR might be a potential target for the diagnosis and treatment of reproductive diseases including infertility.
Defective CFTR-dependent CREB activation results in impaired spermatogenesis and azoospermia.
Wen Ming Xu,Jing Chen,Hui Chen,Rui Ying Diao,Rui Ying Diao,Kin Lam Fok,Jian Da Dong,Ting Ting Sun,Wen Ying Chen,Wen Ying Chen,Mei Kuen Yu,Xiao Hu Zhang,Lai Ling Tsang,Ann S.N. Lau,Qi Xian Shi,Qinghua Shi,Pingbo Huang,Hsiao Chang Chan +17 more
TL;DR: In this article, the role of CFTR and sAC in regulating the cAMP-CREB signaling pathway in Sertoli cells, defect of which may result in impaired spermatogenesis and azoospermia.
81
Cl− Is Required for HCO3− Entry Necessary for Sperm Capacitation in Guinea Pig: Involvement of a Cl−/HCO3− Exchanger (SLC26A3) and CFTR
Wen Ying Chen,Wen Ying Chen,Wen Ming Xu,Zhang Hui Chen,Ya Ni,Yu Ying Yuan,Sichang Zhou,Wen Wei Zhou,Lai Ling Tsang,Yiu Wa Chung,Pia Höglund,Hsiao Chang Chan,Qi Xian Shi +12 more
TL;DR: Capacitation-associated HCO3−-dependent events, including increased intracellular pH, cAMP production, and protein tyrosine phosphorylation, also depend on Cl− concentrations, which indicates that Cl− is required for the entry of H CO3− that is necessary for sperm capacitation.
76
Critical role of CFTR in uterine bicarbonate secretion and the fertilizing capacity of sperm.
Hsiao Chang Chan,Qi Xian Shi,Chen Xi Zhou,Xiao Fei Wang,Wen Ming Xu,Wen Ying Chen,Wen Ying Chen,Ai Jun Chen,Ya Ni,Yu Ying Yuan +9 more
TL;DR: Results are consistent with a critical role of CFTR in controlling uterine HCO3- secretion and sperm fertilizing capacity, suggesting that CFTR may be a potential target for post-meiotic regulation of fertility.
76
Title: Cl - is required for HCO3 - entry necessary for sperm capacitation: involvement of a Cl - /HCO3 - exchanger (SLC26A3) and CFTR in Guinea Pig Short Title: Cl - dependence in capacitation with SLC26A3, CFTR Summary sentence: The Cl - , which is required for HCO3 - entry, is necessary for sperm capacitation with involvement of Cl - /HCO3 - exchanger and CFTR.
Wen Ying Chen,Wen Ming Xu,Zhang Hui Chen,Ya Ni,Yu Ying Yuan,Wen Wei Zhou,Lai Ling Tsang,Yiu Wa Chung,Pia Höglund,Hsiao Chang Chan,Qi Xian Shi +10 more
- 01 Jan 2008