Wen Sun
University of Macau
37 Papers
71 Citations
Wen Sun is an academic researcher from University of Macau. The author has contributed to research in topics: Biology & Chemistry. The author has an hindex of 16, co-authored 30 publications. Previous affiliations of Wen Sun include Chinese Academy of Sciences & Peking Union Medical College.
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Papers
Natural products to prevent drug resistance in cancer chemotherapy: a review
TL;DR: A concise review of two strategies using natural products against drug resistance, including nonapoptotic cell death and drug‐efflux inhibition, are summarized.
186
Cytosolic calcium mediates RIP1/RIP3 complex-dependent necroptosis through JNK activation and mitochondrial ROS production in human colon cancer cells.
Wen Sun,Xiaxia Wu,Hongwei Gao,Jie Yu,Wenwen Zhao,Jin-Jian Lu,Jinhua Wang,Guanhua Du,Xiuping Chen +8 more
TL;DR: It is demonstrated that RIP1/RIP3 complex‐triggered cytosolic calcium accumulation is a critical mediator in MAM‐induced necroptosis through sustained JNK activation and mitochondrial ROS production.
121
Tert-butyl hydroperoxide (t-BHP) induced apoptosis and necroptosis in endothelial cells: Roles of NOX4 and mitochondrion.
TL;DR: It is suggested that t-BHP induced both apoptosis and necroptosis in endothelial cells which was mediated by ROS and p38MAPK.
114
Depletion of BATF in CAR-T cells enhances antitumor activity by inducing resistance against exhaustion and formation of central memory cells.
Xingying Zhang,Chenze Zhang,Miao-Maio Qiao,Chen Cheng,Na Tang,Shan Lu,Wen Sun,Beilei Xu,Yuanwei Cao,Xiaofei Wei,Yao Wang,Weidong Han,Haoyi Wang +12 more
TL;DR: In this paper , the authors performed a candidate gene screen using a hypofunction CAR-T cell model and found that depletion of basic leucine zipper ATF-like transcription factor (BATF) improved the antitumor performance.
71
Tanshinones and diethyl blechnics with anti-inflammatory and anti-cancer activities from Salvia miltiorrhiza Bunge (Danshen).
Hongwei Gao,Wen Sun,Jianping Zhao,Xiaxia Wu,Jin-Jian Lu,Xiuping Chen,Qiongming Xu,Ikhlas A. Khan,Shilin Yang +8 more
TL;DR: The anti-cancer activity investigation indicated that most of isolated compounds exhibited cytotoxicity and the SAR analysis showed that the intact D ring was indispensable and unsaturated D ring played vital role.