Wen Lei
Wayne State University
6 Papers
Wen Lei is an academic researcher from Wayne State University. The author has contributed to research in topics: DNA repair & Cisplatin. The author has an hindex of 5, co-authored 6 publications. Previous affiliations of Wen Lei include Cincinnati Children's Hospital Medical Center.
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Papers
Targeting the DNA Repair Endonuclease ERCC1-XPF with Green Tea Polyphenol Epigallocatechin-3-Gallate (EGCG) and Its Prodrug to Enhance Cisplatin Efficacy in Human Cancer Cells
Joshua Heyza,Sanjeevani Arora,Hao Zhang,Kayla L. Conner,Wen Lei,Ashley M. Floyd,Rahul Deshmukh,Jeffrey G. Sarver,Christopher J. Trabbic,Paul W. Erhardt,Tak Hang Chan,Tak Hang Chan,Q. Ping Dou,Steve M. Patrick +13 more
TL;DR: This study identified the green tea polyphenol (-)-epigallocatechin-3-gallate (EGCG) as a potent inhibitor of ERCC1/XPF activity with an IC50 (half maximal inhibitory concentration) in the nanomolar range in biochemical assays and shows that EGCG can inhibit DNA repair and enhance cisplatin sensitivity in human cancer cells.
Differential role of base excision repair proteins in mediating cisplatin cytotoxicity
TL;DR: The results indicate that BER activation at cisplatin ICLs influences crosslink repair and modulates cisPlatin cytotoxicity via specific UNG, APE1 and Polβ polymerase functions.
38
A dual chicken IgY against rotavirus and norovirus.
Ying-Chun Dai,Xu-Fu Zhang,Xu-Fu Zhang,Ming Tan,Ming Tan,Pengwei Huang,Wen Lei,Hao Fang,Weiming Zhong,Xi Jiang,Xi Jiang +10 more
TL;DR: The data suggested that the P-VP8(∗) based IgY could serve as a practical approach against both NoV and RV, suggesting an application of the IgY as both prophylactic and therapeutic treatment.
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Identification and Characterization of Synthetic Viability with ERCC1 Deficiency in Response to Interstrand Crosslinks in Lung Cancer.
Joshua Heyza,Wen Lei,Donovan Watza,Hao Zhang,Wei Chen,Jessica B. Back,Ann G. Schwartz,Gerold Bepler,Steve M. Patrick +8 more
TL;DR: The findings implicate p53 as a potential confounding variable in clinical assessments of ER CC1 as a platinum biomarker via promoting an environment in which error-prone mechanisms of ICL-R may be able to partially compensate for loss of ERCC1.
Antigenic Relatedness of Norovirus GII.4 Variants Determined by Human Challenge Sera.
Ying-Chun Dai,Xu-Fu Zhang,Ming Xia,Ming Tan,Christina Quigley,Wen Lei,Hao Fang,Weiming Zhong,Bonita E. Lee,Xiao-Li Pang,Jun Nie,Xi Jiang +11 more
TL;DR: The overall abilities of G.II.4 NoVs to bind to the A/B/H HBGAs were maintained while their binding affinities to individual ABH antigens varied, highlighting the importance of human HBGas in NoV evolution and how conserved antigenic types impact vaccine development against GII. 4 variants.