A Systematic Review of the Mysterious Caterpillar Fungus Ophiocordyceps sinensis in DongChongXiaCao (冬蟲夏草 Dōng Chóng Xià Cǎo) and Related Bioactive Ingredients

Osteoporosis is a progressive, systemic bone disorder characterized by loss of bone mass and microstructure, leading to reduced bone strength and increased risk of fracture. It is often associated with reduced quality of life and other medical complications. The disease is common in the aging population, particularly among postmenopausal women and patients who receive long-term steroidal therapy. Given the rapid growth of the aging population, increasing life expectancy, the prevalence of bone loss, and financial burden to the healthcare system and individuals, demand for new therapeutic agents and nutritional supplements for the management and promotion of bone health is pressing. With the advent of global interest in complementary and alternative medicine and natural products, Chinese medicine serves as a viable source to offer benefits for the improvement and maintenance of bone health. This review summarizes the scientific information obtained from recent literatures on the chemical ingredients of Chinese medicinal plants that have been reported to possess osteoprotective and related properties in cell-based and/or animal models. Some of these natural products (or their derivatives) may become promising leads for development into dietary supplements or therapeutic drugs.

https://www.mdpi.com/1420-3049/21/3/239/pdf

Natural Products from Chinese Medicines with Potential Benefits to Bone Health

This study aimed to investigate the efficacy and safety of echinacoside (ECH) using an osteopenia rat model. Forty-eight 6-month-old female Sprague-Dawley rats were randomly divided into one sham-operated group (SHAM) and five OVX (ovariectomized) subgroups: SHAM with vehicle 0.5% carboxymethylcellulose sodium (0.5% CMC-Na) and OVX with vehicle (OVX), OVX with 17β-estradiol (E2), and OVX with ECH of graded doses (ECH-L, ECH-M, and ECH-H). The effects of ECH and E2 on serum biochemical parameters, bone mineral density (BMD), bone biomechanical properties, bone microarchitecture, and immunohistochemistry were examined, and safety assessments were also evaluated. The results showed that ECH treatments improved total femur BMD, bone microarchitecture, and biomechanical properties and decreased serum marker levels in comparison to OVX group. Moreover, ECH administration significantly increased osteoprotegerin (OPG) level, and decreased receptor activator of nuclear factor-κB ligand (RANKL) level in serum, as well as in proximal femur. Importantly, ECH treatment ameliorated the lipid parameters without the overall incidences of adverse events of uterus and mammary gland compared to OVX and SHAM groups. This study demonstrated that administration of ECH for 12 weeks can effectively and safely prevent OVX-induced osteoporosis in rats via increasing the OPG/RANKL ratio.

https://downloads.hindawi.com/journals/ecam/2013/926928.pdf

Efficacy and Safety of Echinacoside in a Rat Osteopenia Model

Summary
Cordyceps sinensis has been known as a traditional medicine in China, and C. sinensis plus strontium could prevent osteoporosis in ovariectomized rats. The present study shows that daily oral administration of C. sinensis at higher doses in adult hind limb suspension rats can prevent disuse-induced bone loss and deterioration of trabecular microarchitecture.

Prevention of disuse osteoporosis in rats by Cordyceps sinensis extract

Metabonomic profiling in studying anti-osteoporosis effects of strontium fructose 1,6-diphosphate on estrogen deficiency-induced osteoporosis in rats by GC/TOF-MS.

The effects of Cordyceps sinensis (Caterpillar fungus) and strontium ranelate on ovariectomized osteopenic rats was studied in this paper. After the rats were treated orally with C. sinensis, strontium, and C. sinensis rich in strontium ranelate (CSS) respectively, serum alkaline phosphatase (ALP), tartarate-resistant acid phosphatase (TRAP), serum osteocalcin (OC), homocysteine, C-terminal crosslinked telopeptides of collagen type I (CTX), estradiol, and interferon-gamma (IFN-γ) level were examined. The beneficial effects of CSS on improvement of osteoporosis in rats were attributable mainly to decrease ALP activity, TRAP activity, CTX level, and IFN-γ level. At the same time, CSS also increase the OC and estradiol level in ovariectomized osteopenic rats. This study demonstrates the value of C. sinensis rich in strontium ranelate in the management of postmenopausal osteoporosis in humans.

The mechanism of Cordyceps sinensis and strontium in prevention of osteoporosis in rats.

: To study the effects of cotton straw returning and deep loosening on cotton yield, salt subsoiling tillage (SRT) were conducted using Lumianyan 36 as experimental material. The results showed that cotton stubble return increased cotton yield across two years. Lint yield of SR was 33.9% higher than CT, and SRT 32.1% higher than SR. Subsoiling increased cotton yield in 2017 and had no effect on it in 2018. Cotton stubble return reduced the salt content of 0–40 cm soil layer. The salt content of SR was 22.4% lower than that of CT, and the soil salt content of SRT was 20.7% lower than that of ST at the late growth stage in cotton. However, the effect of subsoiling on the salt content of 20–40 cm soil layer was incon-sistent during the two-year experiment. The soil salt content of ST was 16.5% lower than of CT at late growth stage in 2017, but subsoiling had no effect on soil salt content in 2018. The accumulation dynamic of dry matter and N, P, K in cotton were consis-tent with the Logistic growth curve. Cotton stubble return increased maximal accumulation of dry matter and N, P, K in two years. The maximum accumulation of dry matter, N, P, and K in SR was 35.5%, 38.3%, 53.4%, and 55.0% higher than that in CT, and the accumulation of SRT was 27.0%, 30.7%, 21.2%, and 42.4% higher than that in ST. Compared with CT, the dry matter, N, P, and K accumulation of ST increased by 17.8%, 22.2%, 51.3%, and 40.6% in 2017, respectively, but had no effect in 2018. The dynamic of dry matter and nutrient accumulation were mainly affected by the maximum accumulation rate and rapid accumulation duration. Stubble return increased the amount and proportion of dry matter and N, P, K allocated to reproductive organs of cotton in the two-year experiment. Compared with CT, ST increased the allocation amount of dry matter and N, P, K to reproductive organs in 2017, but had no effect in 2018. In summary, the results revealed that cotton stubble return (SR) or cotton stubble return + subsoiling tillage (SRT) could be recommended tillage measures for soil improvement and high cotton yield in coastal sa-line-alkali cotton area.

Effects of cotton stubble return and subsoiling on dry matter accumulation, nutrient uptake, and yield of cotton in coastal saline-alkali soil

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The mechanism of Cordyceps sinensis and strontium in prevention of osteoporosis in rats.

Effects of cotton stubble return and subsoiling on dry matter accumulation, nutrient uptake, and yield of cotton in coastal saline-alkali soil