Wen-Jiang Chen

TL;DR: It is found that HIV-1 gp120 induced slower recall antibody responses but redundant non-specific IgG responses at early time after boosting compared to HBsAg, which may provide a direction to improve HIV envelope immunogenicity.

TL;DR: Compared with HBsAg, gp120 induced higher frequencies of Tfh cells and programmed death (PD)-1+ T cells, greater major histocompatibility complex II expression on B cells, but weaker germinal center reactions and memory B cell responses in the draining lymph nodes, accompanied by slower antibody recall responses and poor immune memory responses.

TL;DR: In this paper, an expression method of a high secretory tripolymer protein was proposed, which can be widely applied to viruses which are naturally in the form of tripolymers and the high level secretory expressions of other proteins in the eukaryotic cells.

TL;DR: In this article, an expression method for high-secretory tripolymer protein was proposed, where the N tail end of the target protein was connected with the tPA signal peptide, and the C tail end was connected to the protein trimerization modif protein.