Wen Guo Jiang
Cardiff University
659 Papers
6K Citations
Wen Guo Jiang is an academic researcher from Cardiff University. The author has contributed to research in topics: Cancer & Breast cancer. The author has an hindex of 76, co-authored 649 publications. Previous affiliations of Wen Guo Jiang include University of Stirling & Osaka University.
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Papers
PD-L1 Expression in Glioblastoma, the Clinical and Prognostic Significance: A Systematic Literature Review and Meta-Analysis.
Chengcheng Hao,Gang Chen,Huishan Zhao,Yan Li,Jian-Xin Chen,Hongmei Zhang,Shan Li,Yuze Zhao,Feng Chen,Wenbin Li,Wen Guo Jiang +10 more
TL;DR: It is indicated that high expression of PD-L1 in glioblastoma tumor tissues is associated with poor survival of patients, and PD- L1 may act as a prognostic predictor and an effective therapeutic target for gliOBlastoma.
The cellular distribution of Na+/H+ exchanger regulatory factor 1 is determined by the PDZ-I domain and regulates the malignant progression of breast cancer.
TL;DR: It is shown that NHERF1 was upregulated in high grades compared with low grades, and this redistribution was associated with the malignant phenotype of breast cancer cells, including growth, migration, and adhesion.
The molecular impact of pigment epithelium-derived factor, PEDF, on lung cancer cells and the clinical significance.
TL;DR: It was shown that reduced PEDF levels in lung cancer tissues significantly correlated with lymph node metastasis and an overall poor prognosis in the lung cancer patients.
iASPP is over-expressed in human non-small cell lung cancer and regulates the proliferation of lung cancer cells through a p53 associated pathway
TL;DR: It is concluded that iASPP plays an pivotal role in the progression of lung cancer and is a potential target for lung cancer therapy.
Pigment epithelium-derived factor inhibits angiogenesis via regulated intracellular proteolysis of vascular endothelial growth factor receptor 1.
TL;DR: It is reported that PEDF is able to inhibit growth factor-induced angiogenesis in microvascular endothelial cells through a novel pathway requiring cleavage and intracellular translocation of the transmembrane domain of the VEGFR-1.