32 Papers
5 Citations
Wen Gu is an academic researcher from Nanjing Forestry University. The author has contributed to research in topics: Chemistry & Cytotoxicity. The author has an hindex of 10, co-authored 32 publications.
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Papers
Design, synthesis and biological evaluation of novel β-pinene-based thiazole derivatives as potential anticancer agents via mitochondrial-mediated apoptosis pathway.
TL;DR: The data showed that compound 5g inhibited cell proliferation by inducing apoptosis and cell cycle arrest of Hela cells at the G0/G1 phase in a dose dependent manner, and indicated that compounds 5g induced apoptosis in Hela through ROS-mediated mitochondrial dysfunction signaling pathways.
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Design, synthesis and anticancer activity of novel nopinone-based thiosemicarbazone derivatives
Yunyun Wang,Wen Gu,Shan Yu,Liu Fei,Xu Xu,Yiqin Yang,Qiangjian Zhang,Yan Zhang,Kuang Hongbo,Zhonglong Wang,Shifa Wang +10 more
TL;DR: In the in vitro anticancer activity, most derivatives showed considerable cytotoxic activity against three human cancer cell lines (MDA-MB-231, SMMC-7721 and Hela), and compound 4i exhibited most potent antitumor activity.
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Design, synthesis, and anticancer evaluation of novel quinoline derivatives of ursolic acid with hydrazide, oxadiazole, and thiadiazole moieties as potent MEK inhibitors
TL;DR: In this paper, a series of quinoline derivatives of ursolic acid (UA) bearing hydrazide, oxadiazole, or thiadiazol moieties were designed, synthesised, and screened for their in vitro anti-cancer properties.
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Design, Synthesis, and Antifungal Activity of Novel Thiophene/Furan-1,3,4-Oxadiazole Carboxamides as Potent Succinate Dehydrogenase Inhibitors.
TL;DR: In this paper, 30 thiophene/furan-1,3,4-oxadiazole carboxamide derivatives were designed and synthesized to develop novel Succinate dehydrogenase (SDH) inhibitors.
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Synthesis, in vitro antimicrobial and cytotoxic activities of new carbazole derivatives of ursolic acid
TL;DR: A series of new carbazole derivatives of ursolic acid were designed and synthesized in an attempt to develop potent antimicrobial or antitumor agents, and compound 5e was found to be the most potent compound with IC50 values comparable to those of doxorubicin.
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