5 Papers
Weiyun Sun is an academic researcher from Johns Hopkins University School of Medicine. The author has contributed to research in topics: Medicine & Vacuole. The author has an hindex of 4, co-authored 4 publications.
Chat about Author
Papers
Detection of the ischemic penumbra using pH-weighted MRI
Phillip Zhe Sun,Jinyuan Zhou,Jinyuan Zhou,Weiyun Sun,Judy Huang,Peter C.M. van Zijl,Peter C.M. van Zijl +6 more
TL;DR: Results show that pHWI can provide information complementary to PWI and DWI in the delineation of ischemic tissue and suggest that the outer boundary of the hypoperfused area showing a decrease in pH without DWI abnormality may correspond to the outer boundaries of the isChemic penumbra.
337
Clostridium novyi -NT can cause regression of orthotopically implanted glioblastomas in rats
Verena Staedtke,Ren Yuan Bai,Weiyun Sun,Judy Huang,Kathleen K. Kibler,Betty Tyler,Gary L. Gallia,Kenneth W. Kinzler,Bert Vogelstein,Shibin Zhou,Gregory J. Riggins +10 more
TL;DR: It is shown that intravenously injected spores of C. novyi-NT led to dramatic tumor destructions and significant survival increases in implanted, intracranial syngeneic F98 and human xenograft 060919 rat GBM models, providing pre-clinical data supporting the development of this therapeutic approach for the treatment of patients with GBM.
17β-estradiol attenuates breakdown of blood-brain barrier and hemorrhagic transformation induced by tissue plasminogen activator in cerebral ischemia.
TL;DR: Significant increases in neurological deficits, brain water content, and Evan's blue extravasation were increased in ovariectomized female Wistar rats treated with tPA and attenuated in rats receiving E2+tPA, suggesting a potential role for estrogen in thrombolytic treatment for ischemic stroke.
43
Role of VPS39, a key tethering protein for endolysosomal trafficking and mitochondria-lysosome crosstalk, in health and disease.
TL;DR: The VPS39 subunit of the homotypic fusion and protein sorting complex could play a key role in the regulation of organelle dynamics, such as endolysosomal trafficking and mitochondria-vacuole/lysosome crosstalk, thus contributing to a variety of physiological functions as mentioned in this paper .
2
Suppression of lipid artifacts in amide proton transfer imaging.
Phillip Zhe Sun,Jinyuan Zhou,Jinyuan Zhou,Weiyun Sun,Judy Huang,Peter C.M. van Zijl,Peter C.M. van Zijl +6 more
TL;DR: It was found that unequal pericranial fat saturation at equidistant higher and lower frequencies with respect to water leads to a lipid artifact in APT asymmetry images, and it was demonstrated that a chemical‐shift‐selective refocusing pulse in combination with crusher gradients can suppress this artifact and provide high‐quality images.