Weiya Wang
Amgen
19 Papers
52 Citations
Weiya Wang is an academic researcher from Amgen. The author has contributed to research in topics: TRPM8 & Icilin. The author has an hindex of 15, co-authored 19 publications.
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Papers
Repeated administration of vanilloid receptor TRPV1 antagonists attenuates hyperthermia elicited by TRPV1 blockade.
Narender R. Gavva,Anthony W. Bannon,David N. Hovland,Sonya G. Lehto,Lana Klionsky,Sekhar Surapaneni,David C. Immke,Charles Henley,Leyla Arik,Annette Bak,James Davis,Nadia B. Ernst,Gal Hever,Rongzhen Kuang,Licheng Shi,Rami Tamir,Jue Wang,Weiya Wang,Gary Zajic,Dawn Zhu,Mark H. Norman,Jean-Claude Louis,Ella Magal,James J. S. Treanor +23 more
TL;DR: The in vitro and in vivo characterization of a novel and selective TRPV1 antagonist, AMG 517, and its pharmacology with that of a closely related analog, tert-butyl-2-(6-([2-(acetylamino)-1,3-benzothiazol-4-yl]oxy)pyrimidin- 4-yl)-5-(trifluoromethyl)phenylcarbamate (AMG8163) suggest that
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Species-specific pharmacology of Trichloro(sulfanyl)ethyl benzamides as transient receptor potential ankyrin 1 (TRPA1) antagonists
Lana Klionsky,Rami Tamir,BaoXi Gao,Weiya Wang,David C. Immke,Nobuko Nishimura,Narender R. Gavva +6 more
TL;DR: It is concluded that both human and rat TRPA1 channels show similar AITC and noxious cold activation profiles, but TCEB compounds display species-specific differential pharmacology atTRPA1.
Design and synthesis of quinolin-2(1H)-one derivatives as potent CDK5 inhibitors.
Wenge Zhong,Hu Liu,Matthew R. Kaller,Charles Henley,Ella Magal,Thomas T. Nguyen,Osslund Timothy D,David Powers,Robert M. Rzasa,Hui-Ling Wang,Weiya Wang,Xiaoling Xiong,Jiandong Zhang,Mark H. Norman +13 more
TL;DR: The design, synthesis, and CDK5 inhibitory activities of quinolin-2(1H)-one derivatives are described and used to explore several different chemical series of potentCDK5 inhibitors.
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Selective antagonism of TRPA1 produces limited efficacy in models of inflammatory- and neuropathic-induced mechanical hypersensitivity in rats.
Sonya G. Lehto,Andy D. Weyer,Beth D. Youngblood,Maosheng Zhang,Ruoyuan Yin,Weiya Wang,Yohannes Teffera,Melanie Cooke,Cheryl L. Stucky,Laurie B. Schenkel,Stephanie D. Geuns-Meyer,Bryan D. Moyer,Kenneth D. Wild,Narender R. Gavva +13 more
TL;DR: AMG0902 reduced mechanically evoked C-fiber action potential firing in a skin-nerve preparation from mice previously injected with complete Freund’s adjuvant, supporting the role of TRPA1 in inflammatory mechanosensation and discouraging AITC-induced flinching/licking in rats.
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Mouse Monoclonal Antibodies to Transient Receptor Potential Ankyrin 1 Act as Antagonists of Multiple Modes of Channel Activation
TL;DR: M mice were generated with monoclonal antibodies against TRPA1 that act as antagonists of multiple modes of TRPA2 activation and several of the mAbs showed concentration-dependent inhibition of AITC and cold (4°C) activation ofTRPA1.
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