Weixing Zhang
Peking Union Medical College
7 Papers
Weixing Zhang is an academic researcher from Peking Union Medical College. The author has contributed to research in topics: Chemistry & Medicine. The author has an hindex of 1, co-authored 1 publications.
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Papers
Synthesis and structure-activity relationship of novel bisindole amidines active against MDR Gram-positive and Gram-negative bacteria.
TL;DR: A series of novel diamidines with N-substituents on an amidine N-atom were synthesized and evaluated for their cytotoxicity and in vitro antibacterial activity against a range of Gram-positive and Gram-negative bacterial strains; compounds 5c and 5i were the most powerful candidate compounds.
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A review of progress in o-aminobenzamide-based HDAC inhibitors with dual targeting capabilities for cancer therapy
Weixing Zhang,Jiao Huang,Yunxiao Liu,Mei-Qi Jia,Wang Wang,Cheng-Yun Jin,Jian-Ying Song,Sai-Yang Zhang +7 more
- 01 Jul 2023
TL;DR: The rational design, molecular docking, inhibitory activities and potential application of o-aminobenzamide-based HDAC inhibitors with dual targeting capabilities in cancer therapy are reviewed to provide a reference for developing new and more effective anticancer drugs.
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Tubulin degradation: Principles, agents, and applications.
TL;DR: In this article , the authors reviewed the reports on tubulin degradation, and focused on the degradation mechanism and important functional groups of chemically synthesized compounds, hoping to provide help for the degradation design of tubulin.
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Design, Synthesis and Biological Evaluation of [1,2,4]Triazolo[1,5-a]pyrimidine Indole Derivatives against Gastric Cancer Cells MGC-803 via the Suppression of ERK Signaling Pathway
Guang Yu,Ying Hu,Weixing Zhang,Xin-Yi Tian,Sai-Yang Zhang,Yan Zhang,Shuo Yuan,Jian-Ying Song +7 more
TL;DR: It is reported here that [1,2,4]triazolo[1,5-a]pyrimidine indole derivatives, used as anticancer agents via the suppression of ERK signaling pathway and the most active compound, H12, might be a valuable hit compound for the development of antic cancer agents.
Discovery of novel tranylcypromine-based derivatives as LSD1 inhibitors for gastric cancer treatment.
Qi-Sheng Ma,Yi Fan Zhang,Chenglan Li,Weixing Zhang,Lu-Jiang Yuan,Jinlin Niu,Jian-Ying Song,Sai-Yang Zhang,Hong-Min Liu +8 more
TL;DR: In this paper , a series of tranylcypromine-based derivatives were designed and synthesized, and compound 12u exhibited the most potent inhibitory potency on LSD1 (IC50 = 25.3 nM), and also displayed good antiproliferative effects on MGC-803, KYSE450 and HCT-116 cells with IC50 values of 14.3, 22.8 and 16.3 μM, respectively.
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