Weixiao Sha
Goethe University Frankfurt
7 Papers
40 Citations
Weixiao Sha is an academic researcher from Goethe University Frankfurt. The author has contributed to research in topics: Cytotoxic T cell & T cell. The author has an hindex of 6, co-authored 6 publications.
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Papers
Depletion of tristetraprolin in breast cancer cells increases interleukin-16 expression and promotes tumor infiltration with monocytes/macrophages
TL;DR: It is shown that the loss of TTP in tumors not only affects tumor cell proliferation and survival but also enhances infiltration of MO/MΦ into the tumors, which is typically associated with poor prognosis.
Loss of Nrf2 in bone marrow-derived macrophages impairs antigen-driven CD8(+) T cell function by limiting GSH and Cys availability.
Lisa K. Sha,Weixiao Sha,Laura Kuchler,Andreas Daiber,Annika Klara Giegerich,Andreas Weigert,Tilo Knape,Ryan G. Snodgrass,Katrin Schröder,Ralf P. Brandes,Bernhard Brüne,Andreas von Knethen +11 more
TL;DR: It is demonstrated that reduced levels of GCLM as well as xCT in Nrf2(-/-) BMDMΦ limit GSH availability, thereby inhibiting antigen-induced CD8(+) T cell function.
42
The multi-faceted roles of prostaglandin E2 in cancer-infiltrating mononuclear phagocyte biology.
TL;DR: The impact of PGE(2) on mononuclear phagocytes in inflammation and cancer is summarized and potential implications for cancer therapy are discussed.
22
Necrosis in DU145 prostate cancer spheroids induces COX-2/mPGES-1-derived PGE2 to promote tumor growth and to inhibit T cell activation.
TL;DR: Targeting microsomal PGE synthase 1, the downstream enzyme in the COX‐2‐dependent pathway of PGE2 production might be attractive, although conflicting data regarding a potential tumor‐supporting function of mPGES‐1 were reported.
20
MPGES-1-derived PGE2 suppresses CD80 expression on tumor-associated phagocytes to inhibit anti-tumor immune responses in breast cancer
Catherine Olesch,Weixiao Sha,Carlo Angioni,Lisa Katharina Sha,Elias Açaf,Paola Patrignani,Per-Johan Jakobsson,Heinfried H. Radeke,Sabine Grösch,Gerd Geisslinger,Andreas von Knethen,Andreas Weigert,Bernhard Brüne +12 more
TL;DR: It is proposed that mPGES-1 inhibition in combination with immune cell activation might be part of a therapeutic strategy to overcome the immunosuppressive tumor microenvironment.