Weiwei Lin
10 Papers
Weiwei Lin is an academic researcher. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 6, co-authored 10 publications.
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Papers
Low-intensity pulsed ultrasound promotes skeletal muscle regeneration via modulating the inflammatory immune microenvironment
Haocheng Qin,Zhiwen Luo,Yaying Sun,Zhong-qin He,Beijie Qi,Yisheng Chen,Junlong Wang,Ce Li,Weiwei Lin,Zhihua Han,Yulian Zhu +10 more
TL;DR: In this paper , low-intensity pulsed ultrasound (LIPUS) was applied in vivo for 5 min at two different intensities (30mW/cm2) in next 7 consecutive days, and the treatment begun at 24h after air drop-induced contusion injury.
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Single-cell transcriptome analysis reveals the immune heterogeneity and the repopulation of microglia by Hif1α in mice after spinal cord injury
Jingyu Wang,Lintao Xu,Weiwei Lin,Ying Yao,Heyangzi Li,Gerong Shen,Xi Cao,Ning He,Jun Chen,Jue Hu,Mingzhu Zheng,Xinghui Song,Yuemin Ding,Yue-Liang Shen,Jinjie Zhong,Lin-Lin Wang,Ying-ying Chen,Yongjian Zhu +17 more
TL;DR: In this paper , the authors used single-cell RNA sequencing to portray the dynamic transcriptional landscape of immune cells during the early and late phases of spinal cord injury in mice and found that residual microglia regress to a developmental growth state in the early stages after SCI.
Exercise Modifies the Transcriptional Regulatory Features of Monocytes in Alzheimer’s Patients: A Multi-Omics Integration Analysis Based on Single Cell Technology
Yisheng Chen,Yaying Sun,Zhiwen Luo,Xiangjun Chen,Yian Wang,Beijie Qi,Jinrong Lin,Weiwei Lin,Chenyu Sun,Yifan Zhou,Jiebin Huang,Yuzhen Xu,Jiwu Chen,Shiyi Chen +13 more
TL;DR: The constructed network reveals the mechanism by which exercise regulated monocytes to confer therapeutic benefits against Alzheimer’s disease and its complications, and requires further experimental validation.
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Exercise improves choroid plexus epithelial cells metabolism to prevent glial cell-associated neurodegeneration
Yisheng Chen,Zhiwen Luo,Yaying Sun,Fangqi Li,Zhihua Han,Beijie Qi,Jinrong Lin,Weiwei Lin,Meng-Kan Yao,Xue-Ran Kang,Jiebin Huang,Chenyu Sun,Chenting Ying,Chenyang Guo,Yuzhen Xu,Jiwu Chen,Shiyi Chen +16 more
TL;DR: Single-cell analysis of brain tissue from young and old mice showed that CPC age heterogeneity-associated proteins might be directly targeted by the metabolite of oxidized glutathione (GSSG), and insight into GSSG’s targeting function and free-energy barrier was confirmed.
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Quercetin targets VCAM1 to prevent diabetic cerebrovascular endothelial cell injury
Jiebin Huang,Weiwei Lin,Yuxing Sun,Qian Wan,S. He,Zhihua Han,Lixing Lu,Xue-Ran Kang,Yisheng Chen,Haoran Guo,Zhiyong Cui,Chenyu Sun,K. Go,Junyi Wu,Meng-Kan Yao,Ming-feng Cao,Yuzhen Xu +16 more
TL;DR: Molecular docking results of the quercetin-VCAM1 complex suggest that quercETin may be an effective drug for targeting this protein, and EC_EndMT subtypes have a complex role in neurodegenerative diseases caused by diabetes.