Weiwei Dai
Pennsylvania State University
5 Papers
Weiwei Dai is an academic researcher from Pennsylvania State University. The author has contributed to research in topics: Internal medicine & Chemistry. The author has an hindex of 4, co-authored 5 publications.
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Papers
ATF4-Mediated Upregulation of REDD1 and Sestrin2 Suppresses mTORC1 Activity during Prolonged Leucine Deprivation
Dandan Xu,Weiwei Dai,Lydia Kutzler,Holly A. Lacko,Leonard S. Jefferson,Michael D. Dennis,Scot R. Kimball +6 more
TL;DR: The results suggest that leucine deprivation upregulates expression of both REDD1 and Sestrin2 in an ATF4-dependent manner, and that upregulatedexpression of both proteins is involved in resuppression of mTORC1 during prolonged leucINE deprivation.
Deletion of the Akt/mTORC1 Repressor REDD1 Prevents Visual Dysfunction in a Rodent Model of Type 1 Diabetes.
William P. Miller,Chen Yang,Maria L. Mihailescu,Joshua A. Moore,Weiwei Dai,Alistair J. Barber,Michael D. Dennis +6 more
TL;DR: A role for REDD1 in diabetes-induced retinal neurodegeneration is supported, and diabetic wild-type mice exhibited functional deficiencies in visual acuity and contrast sensitivity, whereas diabetic REDD 1-deficient mice had no visual dysfunction.
Consumption of a high fat diet promotes protein O-GlcNAcylation in mouse retina via NR4A1-dependent GFAT2 expression.
TL;DR: Results support a model wherein HFD increases retinal protein O-GlcNAcylation by promoting NR4A1-dependent GFAT2 expression, and inhibition of the pathway's rate-limiting enzyme glutamine-fructose-6-phosphate amidotransferase (GFAT) prevented Cer6-induced O- GlcNACylation.
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Deletion of the stress-response protein REDD1 promotes ceramide-induced retinal cell death and JNK activation.
Weiwei Dai,William P. Miller,Allyson L. Toro,Adam J. Black,Sadie K. Dierschke,Robert P. Feehan,Scot R. Kimball,Michael D. Dennis +7 more
TL;DR: The results support a model wherein Cer‐induced REDD1 expression attenuates TXNIP‐dependent JNK activation and retinal cell death, and both Western diet and C6‐Cer exposure enhanced expression of the stress‐response protein regulated in development and DNA damage response 1 (REDD1).
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High-Fat Diet/Palmitate–Induced ER Stress Promotes Protein O-GlcNAcylation in Retina and Retinal Muller Cells
TL;DR: A model whereby HFD-induced ER stress acts to promote O-GlcNAcylation in retina through an OASIS/GFAT2-dependent mechanism is supported, as dysregulated O- glial cell specific transcription factor OASis plays a central role in coordinating the unfolded protein response.
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