Weiping Chen
Fourth Military Medical University
35 Papers
179 Citations
Weiping Chen is an academic researcher from Fourth Military Medical University. The author has contributed to research in topics: Enantioselective synthesis & Catalysis. The author has an hindex of 12, co-authored 35 publications.
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Papers
Ferrocene as a Privileged Framework for Chiral Organocatalysts
TL;DR: Ferrocene (Fc) as a privileged framework for chiral organocatalysts (Orgcat) has been developed rapidly in recent years as discussed by the authors, and five categories of them including Fc-based nucleophilic, bifunctional, Bronsted acid, hydrogen-bonding and frustrated Lewis pairs were summarized.
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Highly enantioselective hydrogenation of 2-substituted-2-alkenols catalysed by a ChenPhos–Rh complex
TL;DR: Highly enantioselective hydrogenation of a variety of 2-substituted-2-alkenols has been achieved using a ChenPhos-Rh complex as catalyst, giving ≥99% ee for most substrates.
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Asymmetric hydrogenation of aromatic ketones using an iridium(I) catalyst containing ferrocene-based P-N-N tridentate ligands
TL;DR: In this paper, six ferrocene-based P-N-N tridentate ligands have been synthesized and applied in the Ir-catalyzed asymmetric hydrogenation of aromatic ketones.
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Synthesis of spiro-tetrahydrothiopyran-oxindoles by Michael-aldol cascade reactions: discovery of potential P53-MDM2 inhibitors with good antitumor activity.
Shengzheng Wang,Shuqiang Chen,Zhongjie Guo,Shipeng He,Fan Zhang,Xueying Liu,Weiping Chen,Shengyong Zhang,Chunquan Sheng +8 more
TL;DR: Using proline as the catalyst, an organocatalytic Michael-aldol cascade reaction was developed for the synthesis of spiro-tetrahydrothiopyran oxindoles, which displayed moderate to good in vitro antitumor activities and were validated as p53-MDM2 inhibitors.
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Bifunctional ferrocene-based squaramide-phosphine as an organocatalyst for highly enantioselective intramolecular Morita–Baylis–Hillman reaction
TL;DR: This work demonstrates that, in accord with metal catalysis, ferrocene could be an excellent scaffold for organocatalysts.
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