Weimin Wang
Sirna Therapeutics
10 Papers
1.1K Citations
Weimin Wang is an academic researcher from Sirna Therapeutics. The author has contributed to research in topics: Oligonucleotide & Small interfering RNA. The author has an hindex of 7, co-authored 10 publications.
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Papers
Patent
RNA INTERFERENCE MEDIATED INHIBITION OF GENE EXPRESSION USING CHEMICALLY MODIFIED SHORT INTERFERING NUCLEIC ACID (siNA)
James McSwiggen,Bharat Chowrira,Leonid Beigelman,Dennis G. Macejak,Shawn Zinnen,Pamela Pavco,Peter Haeberli,David Morrissey,Kathy Fosnaugh,Sharon Jamison,Nassim Usman,James Thompson,Chandra Vargeese,Weimin Wang,Tongqian Chen,Narendra K. Vaish +15 more
- 04 Aug 2006
TL;DR: In this article, the authors present methods and reagents useful for modulating gene expression in various applications such as therapeutic, diagnostic, target assessment and genome discovery applications, which relates to synthetic chemically modified small nucleic acid molecules capable of mediating RNA interference (RNAi) to a target NCA sequence, such as short interfering nucleic acids (siNA), short interfering RNA (siRNA).
475
Patent
Conjugates and compositions for cellular delivery.
Chandra Vargeese,Peter Haeberli,Weimin Wang,Tongqian Chen +3 more
- 17 May 2002
TL;DR: In this paper, the folate derived conjugates of nucleosides, nucleotides, non-nucleosides and nucleic acids including enzymes and antisense nucleic acid molecules are described.
302
Patent
Lipid nanoparticle based compositions and methods for the delivery of biologically active molecules
Tongqian Chen,Chandra Vargeese,Kurt Vagle,Weimin Wang,Ye Zhang +4 more
- 14 Feb 2006
TL;DR: In this paper, formulated molecular compositions (FMC) or lipid nanoparticles (LNP) are defined for the study, diagnosis, and treatment of traits, diseases and conditions that respond to the modulation of gene expression and/or activity in a subject or organism.
220
Patent
Polycationic compositions for cellular delivery of polynucleotides
Chandra Vargeese,Weimin Wang,Tongqian Chen,David Sweedler,Peter Haeberli +4 more
- 09 Jul 2004
TL;DR: In this article, the authors proposed a method for delivering biologically active molecules to cells by using polycationic compositions, polymers and methods for delivering nucleic acid, polynucleotide, and oligonucleotides such as RNA, DNA and analogs thereof.
102
Novel liver-specific TORC2 siRNA corrects hyperglycemia in rodent models of type 2 diabetes
Maziyar Saberi,David Bjelica,Simon Schenk,Takeshi Imamura,Gautam Bandyopadhyay,Pingping Li,Vasant Jadhar,Chandra Vargeese,Weimin Wang,Keith Bowman,Ye Zhang,Barry Polisky,Jerrold M. Olefsky +12 more
TL;DR: The importance of TORC2 in modulating HGP in vivo is demonstrated and a novel, liver-specific siRNA approach for the potential treatment of hyperglycemia and type 2 diabetes is highlighted.
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